52-49-3 Usage
Description
Trihexyphenidyl is an antagonist of M1 muscarinic acetylcholine receptors. It binds to rat M1 receptors in cerebral cortex selectively over rat M2 receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine in guinea pig ileum (IC50 = 22 nM). It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH). Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson''s disease.
Chemical Properties
Benzhexol hydrochloride is White Solid
Uses
Different sources of media describe the Uses of 52-49-3 differently. You can refer to the following data:
1. anticholinergic, antiparkinsonian
2. Benzhexol hydrochloride is an anticholinergic tertiary amine that can gain access to the CNS. It is used to treat parkinsonism and the extrapyramidal side effects of anti-psychotic drugs. The drug is a muscarinic anta gonist that qualitatively resembles the belladonna alkaloids in its pharmacological actions and side effects.
Therapeutic Function
Antiparkinsonian
General Description
Trihexyphenidylhydrochloride, α-cyclohexyl-α-phenyl-1-piperidinepropanolhydrochloride (Artane, Tremin, Pipanol), introduced in1949, is approximately half as active as atropine as an antispasmodicbut is claimed to have milder side effects, such asmydriasis, drying of secretions, and cardioacceleration. It hasa good margin of safety, although it is about as toxic as atropine.It has found a place in the treatment of parkinsonismand is claimed to provide some measure of relief from themental depression often associated with this condition. It does, however, exhibit some of the side effects typical of theparasympatholytic-type preparation, although adjusting thedose carefully may often eliminate these.
Safety Profile
Poison by ingestion,intraperitoneal, intravenous, and subcutaneous routes. Ananticholinergic agent which causes human psychotropiceffects. Human systemic effects by ingestion: distortedperceptions, eye effects, hallucinations, toxic psychosis.When he
Check Digit Verification of cas no
The CAS Registry Mumber 52-49-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 52-49:
(4*5)+(3*2)+(2*4)+(1*9)=43
43 % 10 = 3
So 52-49-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H31NO.2ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;2*1H
52-49-3Relevant articles and documents
Synthetic method of diphenhydrazide hydrochloride
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Paragraph 0015-0019, (2020/11/22)
The invention discloses a synthetic method of diphenhydrazide hydrochloride, and researches find that the yield of a diphenhydrazide hydrochloride crude product is more than 85% by using a mixed solvent of methyl tert-butyl ether and ethylene glycol dimethyl ether and adjusting specific parameters and an operation method of a production process at the same time. The purity of the crude diphenhydrazol hydrochloride product is greater than 98%. According to the method, the yield and quality of diphenhydrazide hydrochloride are greatly improved, the production is safer, and the industrializationis facilitated.
Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury
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, (2008/06/13)
Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows such conditions as stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of an aryl-cycloalkyl-alkanolamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites.
