5203-12-3

Upstream product

• 2623-91-8 (R)-2-aminobutyric acid 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 1242459-34-2 C₁₈H₂₇NO₄Si₂ 
• 105763-26-6 (2R,3R)-1,2-O-isopropylidene-3-phthalimidopentane-1,2-diol 
• 105763-29-9 (2R,3R)-1,2-O-isopropylidene-3-phthalimidepent-4-ene-1,2-diol 
• 100373-15-7 (2R,3R)-3-phthalimidopentane-1,2-diol 
• 105763-36-8 (2R,3R)-3-phthalimidopent-4-ene-1,2-diol 
• 105763-39-1 (R)-2-phthalimido-3-butenal 
• 136918-14-4 phthalimide 
• 105763-40-4 (R)-2-phthalimido-4-butenoic acid 
• 105816-56-6 (R)-2-phthalimidobutanal 

Downstream Products

• 2623-91-8 (R)-2-aminobutyric acid 

Relevant academic research and scientific papers

PYRROLIDINE DERIVATIVE

The present invention aims to provide a novel compound which has CGRP receptor antagonist activity and which is useful for the treatment of various diseases mediated by CGRP receptors. That is, the present invention relates to the pyrrolidine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. In the formulae, W is ring, X is a carbon atom or the like, Y1 to Y4 are carbon atoms or the like, and R1 to R7 is alkyl or the like. The compounds of the present invention or a pharmaceutically acceptable salt thereof have an excellent CGRP receptor antagonist activity, and thus are useful as agents for the treatment of various diseases mediated by CGRP receptors.

Catalytic asymmetric protonation of α-amino acid-derived ketene disilyl acetals using P -Spiro diaminodioxaphosphonium barfates as chiral proton

Chiral diaminodioxaphosphonium salts have been developed and their unique abilities as a chiral proton have been revealed through the establishment of a highly enantioselective protonation of α-amino acid-derived ketene disilyl acetals.

A General and Practical Synthesis of (R)-Phthalimido Aldehydes and D-α-Amino Acids from D-Mannitol

A short and practical synthesis of five D-α-amino acids is described from D-mannitol as the chiral educt.The key steps in the sequence are (a) the erythro-selective addition of organometals to (R)-2,3-O-isopropylideneglyceralaldehyde, (b) the Mitsunobu inversion substituting N-phthalimide for hydroxyl, and (c) acetonide hydrolysis and glycol cleavage to give the N -phthaloyl-(R)-α-aminoaldehydes 7.These are oxidized under Jones conditions to give the N-protected amino acids 8.The examples investigated (alanine, aminobutyric acid, norvaline, and allyl- and vinylglycine) demonstrate the general applicability of the method.