52031-69-3

Basic information

• Product Name: (2E)-3-(1-naphthyl)acryloyl chloride
• Synonyms: (2E)-3-(1-naphthyl)acryloyl chloride;2-propenoyl chloride, 3-(1-naphthalenyl)-, (2E)-;(E)-3-(1-naphthyl)acryloyl chloride;(E)-3-(1-naphthyl)prop-2-enoyl chloride;(E)-3-naphthalen-1-ylprop-2-enoyl chloride;3-Naphthalen-1-yl-acryloyl chloride
• CAS NO: 52031-69-3
• Molecular Formula: C₁₃H₉ClO
• Molecular Weight: 216.66296
• Mol File: 52031-69-3.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2E)-3-(1-naphthyl)acryloyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(1-naphthyl)acryloyl chloride(52031-69-3)
• EPA Substance Registry System: (2E)-3-(1-naphthyl)acryloyl chloride(52031-69-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 52031-69-3(Hazardous Substances Data)

Upstream product

• 13026-12-5 3-(1-naphthyl)propenoic acid 
• 98978-43-9 (E)-ethyl 3-(naphthalen-1-yl)acrylate 
• 66-77-3 1-naphthaldehyde 
• 13026-12-5 (E)-3-(naphthalen-1-yl)acrylic acid 

Downstream Products

• 85992-25-2 1-chloronaphtho<2,1-b>thiophene-2-carboxoyl chloride 
• 63293-73-2 C₂₅H₂₅NO₄ 
• 56252-02-9 2-hydroxy-9-(4-hydroxyphenyl)-1H-phenalen-1-one 
• 65874-44-4 2-hydroxy-9-(4'-methoxyphenyl)-1H-phenalen-1-one 
• 65874-43-3 9-(4-methoxyphenyl)-1H-phenalen-1-one 
• 548-39-0 Perinaphthenon 
• 1333163-20-4 (E)-N-(4-(3-chlorophenylamino)quinazolin-6-yl)-3-(naphthalen-4-yl)acrylamide 
• 1205684-39-4 C₃₈H₃₀NOPS 

Relevant articles and documents

Practical access to fluorescent 2,3-naphthalimide derivatives: Via didehydro-Diels-Alder reaction

A practical and efficient approach for the synthesis of fluorescent 2,3-naphthalimide derivatives has been developed from readily available starting materials via an intramolecular didehydro-Diels-Alder reaction, which proceeded well under room temperature, exhibiting a wide substrate scope and good functional group tolerance. The practicability of this methodology has been verified by one-step synthesis of the environmentally sensitive fluorophore 6-DMN on a gram scale with a shorter time, fewer steps and less waste disposal, and without the utilization of toxic transition metals. The present experimental and computational studies support the crucial role of the propiolimide moiety in the transformation.

Enantioselective Synthesis of 3,4-Dihydropyran-2-ones via Phase-Transfer-Catalyzed Addition-Cyclization of Acetylacetone to Cinnamic Thioesters

Herein, we present the first example of synthesis of 3,4-dihydropyran-2-ones from cinnamic thioesters via a stereoselective phase-transfer-catalyzed domino Michael-cyclization reaction with acetylacetone. The reaction proceeded under the catalysis of Cinchona-derived quaternary ammonium phenoxide that, in combination with inorganic bases, provided 3,4-dihydropyran-2-ones in yields of up to 93% and enantioselectivities of up to 88% enantiomeric excess.

Concise Synthesis of Natural Phenylphenalenone Phytoalexins and a Regioisomer

Concise total syntheses of the natural phytoalexins 2-hydroxy-8-(4-hydroxyphenyl)phenalen-1-one (1), 2-hydroxy-8-(3,4-dihydroxyphenyl)phenalen-1-one (2), and hydroxyanigorufone (4), together with regioisomer 3 are accomplished in 11 or 12 steps. The synthetic strategy features a Friedel-Crafts acylation to construct the 1H-phenalen-1-one tricyclic core followed by a Suzuki cross-coupling to obtain the target compounds.