52039-23-3Relevant academic research and scientific papers
Preparation of Amino(diethoxyphosphoryl)acetic Esters. Catalytic Hydrogenation of Diazo Compounds to Amines
Shiraki, Chihiro,Saito, Hiromitsu,Takahashi, Keiichi,Urakawa, Chikahiro,Hirata, Tadashi
, p. 399 - 401 (1988)
tert-Butyl amino(diethoxyphosphoryl)acetate (2a) is prepared on a multigram scale from tert-butyl diethoxyphosphorylacetate (1a) in a facile two-step synthesis.The method involves the formation of diazo derivative 4 and subsequent catalytic hydrogenation.Compound 2a is also synthesized by reduction of the oxime derivative 3.Direct amination of diethoxyphosphorylacetic esters with chloramine gives other types of esters 2b-e in addition to the tert-butyl ester 2a.
