52043-21-7

Usage

Type of chemical

Synthetic herbicide

Function

Controls a broad spectrum of annual and perennial grass weeds in various crops

Mode of action

Inhibits the enzyme acetyl-CoA carboxylase, which is essential for fatty acid synthesis in targeted plants

Effect on plants

Disrupts the plant's ability to produce essential lipids and ultimately leads to its death

Common uses

Wheat, barley, and other cereal crops

Application method

Post-emergence treatment

Toxicity

Low toxicity to mammals and non-target organisms when used according to label instructions

Precautions

Handle and apply with proper precautions to minimize potential health and environmental risks.

InChI:InChI=1/C9H8F2O3/c1-5(9(12)13)14-8-3-2-6(10)4-7(8)11/h2-5H,1H3,(H,12,13)

Upstream product

• 1052722-39-0 2-(2,4-difluoro-phenoxy)-propionic acid ethyl ester 
• 367-27-1 2,4-difluorophenol 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS)

The increasing prevalence of drug-resistant bacterial infections is driving the discovery and development not only of new antibiotics, but also of inhibitors of virulence factors that are crucial for in vivo pathogenicity. One such virulence factor is the type III secretion system (T3SS), which plays a critical role in the establishment and dissemination of Pseudomonas aeruginosa infections. We have recently described the discovery and characterization of a series of inhibitors of P. aeruginosa T3SS based on a phenoxyacetamide scaffold. To better characterize the factors involved in potent T3SS inhibition, we have conducted a systematic exploration of this structure, revealing several highly responsive structure-activity relationships indicative of interaction with a specific target. Most of the structural features contributing to potency were additive, and combination of those features produced optimized inhibitors with IC50 values 1 μM.