52045-42-8 Usage
Uses
Used in Organic Synthesis:
4-fluoro-2-methyl-1-indanone is utilized as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure and functional groups make it a valuable intermediate in the synthesis of specialty chemicals and pharmaceuticals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-fluoro-2-methyl-1-indanone serves as a key precursor in the development of new drugs. Its versatile reactivity allows for the modification and functionalization of its structure, which can lead to the discovery of novel therapeutic agents with improved pharmacological properties.
Used in Chemical Industry:
4-fluoro-2-methyl-1-indanone is also employed as a precursor in the manufacturing of other chemicals. Its presence in the synthesis process can enhance the properties of the final product, such as stability, solubility, or reactivity, making it suitable for a wide range of applications in the chemical sector.
Check Digit Verification of cas no
The CAS Registry Mumber 52045-42-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,0,4 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 52045-42:
(7*5)+(6*2)+(5*0)+(4*4)+(3*5)+(2*4)+(1*2)=88
88 % 10 = 8
So 52045-42-8 is a valid CAS Registry Number.
52045-42-8Relevant academic research and scientific papers
Nickel-Catalyzed Domino Heck-Type Reactions Using Methyl Esters as Cross-Coupling Electrophiles
Zheng, Yan-Long,Newman, Stephen G.
supporting information, p. 18159 - 18164 (2019/11/13)
While esters are frequently used as traditional electrophiles in substitution chemistry, their application in cross-coupling chemistry is still in its infancy. This work demonstrates that methyl esters can be used as coupling electrophiles in Ni-catalyzed Heck-type reactions through the challenging cleavage of the C(acyl)?O bond under relatively mild reaction conditions at either 80 or 100 °C. With the σ-NiII intermediate generated from the insertion of acyl NiII species into the tethered C=C bond, carbonyl-retentive products were formed by domino Heck/Suzuki–Miyaura coupling and Heck/reduction pathways when organoboron and mild hydride nucleophiles are used.
PROCESS FOR THE PREPARATION OF 6-FLUORO-2-METHYL-1-INDANONE
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Page/Page column 5-7, (2008/06/13)
A process for the preparation of 6-fluoro-2-methyl-l-indanone which relates to a process of preferential cyclization of (3-fluorophenyl)-isopropenyl-ketone to obtain 6-fluoro-2-methyl- 1-indanone regioisomer with respect to 4-fluoro-2-methyl-l-indanone regioisomer, is described.
