52052-66-1 Usage
Uses
Used in Pharmaceutical Industry:
(4R,5R,αR)-1,3,4,5-Tetrahydro-4-(methylamino)-α-(1-methylethenyl)benz[cd]indole-5-methanol is used as a pharmaceutical compound for its potential therapeutic applications. Its unique structure and properties make it a promising candidate for the development of new drugs targeting various medical conditions.
Used in Research and Development:
In the field of research and development, (4R,5R,αR)-1,3,4,5-Tetrahydro-4-(methylamino)-α-(1-methylethenyl)benz[cd]indole-5-methanol serves as a valuable compound for studying its chemical properties, interactions with biological systems, and potential applications in drug discovery.
Used in Chemical Synthesis:
This ergot type alkaloid can also be utilized as a key intermediate in the synthesis of other complex organic molecules, particularly those with potential pharmaceutical or biological activities. Its unique structure and functional groups make it a versatile building block for the development of novel compounds.
References
Tscherter, Hartmut., Helv. Chim. Acta, 57, 113 (1974)
Check Digit Verification of cas no
The CAS Registry Mumber 52052-66-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,0,5 and 2 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 52052-66:
(7*5)+(6*2)+(5*0)+(4*5)+(3*2)+(2*6)+(1*6)=91
91 % 10 = 1
So 52052-66-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H20N2O/c1-9(2)16(19)15-11-5-4-6-12-14(11)10(8-18-12)7-13(15)17-3/h4-6,8,13,15-19H,1,7H2,2-3H3/t13-,15-,16+/m1/s1
52052-66-1Relevant articles and documents
TOTAL SYNTHESES OF CLAVINE ALKALOIDS BY AN INTRAMOLECULAR NITRONE-OLEFIN CYCLOADDITION REACTION
Oppolzer, W.,Grayson, J. I.,Wegmann, H.,Urrea, M.
, p. 3695 - 3706 (2007/10/02)
The racemic ergot alkaloids chanoclavine I (1) and 6,7-secoagroclavine (4) have been synthesized stereoselectively from indole-4-carboxaldehyde (7) in overall yields of 14 and 13 percent, respectively.Further syntheses of isochanoclavine I (2), paliclavine (5) and costaclavine (6), via the same isoxazolidine 18 are described.The key step 16-->18 (Scheme 4) involves a transient nitrone 17 which undergoes a kinetically controlled, regio- and stereoselective intramolecular cycloaddition to a 1,2-disubstituted olefinic bond.
Intramolecular Nitrile Oxide Cycloaddition (INOC) Reactions in the Indole Series. 2. Total Synthesis of Racemic and Optically Active Paliclavine and 5-epi-Paliclavine
Kozikowski, Alan P.,Chen, Yon-Yih
, p. 5248 - 5250 (2007/10/02)
The first total synthesis of the ergot alkaloid paliclavine and the formal total synthesis of paspaclavine in optically active form are described.
