52059-63-9Relevant academic research and scientific papers
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1)
Mayhoub, Abdelrahman S.,Marler, Laura,Kondratyuk, Tamara P.,Park, Eun-Jung,Pezzuto, John M.,Cushman, Mark
, p. 7030 - 7039 (2013/01/15)
NAD(P)H:quinone reductase 1 (QR1) belongs to a class of enzymes called cytoprotective enzymes. It exhibits its cancer protective activity mainly by inhibiting the formation of intracellular semiquinone radicals, and by generating α-tocopherolhydroquinone, which acts as a free radical scavenger. It is therefore believed that QR1 inducers can act as cancer chemopreventive agents. Resveratrol (1) is a naturally occurring stilbene derivative that requires a concentration of 21 μM to double QR1 activity (CD = 21 μM). The stilbene double bond of resveratrol was replaced with a thiadiazole ring and the phenols were eliminated to provide a more potent and selective derivative 2 (CD = 2.1 μM). Optimizing the substitution pattern of the two phenyl rings and the central heterocyclic linker led to a highly potent and selective QR1 inducer 9o with a CD value of 0.087 μM.
Herbicidal isoxazole and isothiazole-5-carboxamides
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, (2008/06/13)
There are provided isoxazole- and isothiazole-5-carboxamide compounds of formula I STR1 which are useful for the control of undesirable monocotyledenous and dicotyledenous plant species in the presence of crops such as cereal and leguminous crops. Also pr
Isoxazole- and isothiazole-5-carboxamide derivatives, their preparation and their use as herbicides
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, (2008/06/13)
There are provided isoxazole- and isothiazole-5-carboxamide compounds of formula I wherein X represents an oxygen or sulfur atom; W represents an optionally substituted alkyl, alkenyl, cycloalkyl, diakylamino, aryl, heteroaryl or aralkyl group; Y represen
