52063-44-2

Upstream product

• 1008-75-9 3-methyl-5-phenylisoxazole 
• 20900-97-4 4-(p-nitrophenyl)-3-buten-2-one oxime 
• 75624-78-1 <3-(4-Nitrophenyl)-5-isoxazolylmethyl>triphenylphosphonium-chlorid 
• 555-16-8 4-nitrobenzaldehdye 
• 946-49-6 4-(p-nitrophenyl)-3-butene-2-one 
• 21791-84-4 (2Z,3E)-4-(4-nitrophenyl)but-3-en-2-one oxime 

Downstream Products

• 64656-94-6 4-(3-methyl-isoxazol-5-yl)-aniline 
• 1356599-28-4 3-(5-{4-[(4-{[(2E,2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)amino]phenyl}-3-methyl-1,2-oxazol-4-yl)propanoic acid 
• 1356600-50-4 4-iodo-3-methyl-5-(4-nitrophenyl)-1,2-oxazole 
• 1356600-52-6 methyl (2E,2Z)-3-[3-methyl-5-(4-nitrophenyl)-1,2-oxazol-4-yl]acrylate 
• 1356600-54-8 methyl 3-[5-(4-aminophenyl)-3-methyl-1,2-oxazol-4-yl]propanoate 
• 1356600-57-1 methyl 3-(5-{4-[(4-{[(2E,2Z)-2-(4-cyanophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)amino]phenyl}-3-methyl-1,2-oxazol-4-yl)propanoate 

Relevant academic research and scientific papers

Substituted 2,3-dihydroisoxazoles (Δ4-isoxazolines) via palladium- mediated cyclization of propargylic N-hydroxyureas

Aryl-substituted propargylic N-hydroxyureas cyclize in the presence of catalytic Pd(OAc)2 to yield 2,3-dihydroisoxazoles.

Preparation method of isoxazole derivative

The invention relates to a preparation method of an isoxazole derivative, which comprises the following steps of mixing an propargyl alcohol derivative, a halogen source, an acid and a solvent, and heating to react; adding the hydroxylamine into the react

AGONISTS OF GPR40

The present invention relates to compounds that have the ability to modulate the activity of GPR40 and are there-fore useful in the treatment of GPR40 related disorders. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders related to GPR40 activity.

Synthesis of 3-Substituted 5-Arylisoxazoles from α,β-Unsaturated Oximes

The synthesis of 3-substituted 5-arylisoxazoles from oximes of α,β-unsaturated ketones is studied. The formation of the isoxazole derivatives takes place by cyclization of oximes in the presence of iodine and potassium iodide. The presence of isoxazoline

Reactions with Organophosphorus Compounds, XLVI. Reactivity Umpolung of 1,3-Dioxo Compounds through Introduction of a Triphenylphosphonio Group. - Regioselective Syntheses of Isoxazoles and Pyrazoles from (2,4-Dioxoalkyl)triphenylphosphonium Salts

Phosphonium salts 2 and 6, upon deprotonation with BuLi and subsequent reaction with acyl halides, yield the γ-acyl derivatives 3 and 7, respectively, which on treatment with hydrochloric acid afford the corresponding (dioxoalkyl)phosphonium salts 4 and 8.Isoxazole derivatives 9 and 10 are formed regioselectivly from 4 and 8 with NH2OH*HCl, while with R-NH-NH2*HCl (R = H or C6H5) the pyrazole-containing phosphonium salts 14 and 15 are obtained in an analogous reaction.In each case the direction of cyclisation is different to the reactions of the corresponding non-phosphorus substituted 1,3-dioxo compounds.On treatment with aqueous NaOH 9 and 10 are cleaved to triphenylphosphane oxide and isoxazoles 11 and 12, while 14 and 15 yield the pyrazoles 16 and 17.Wittig reaction of 9a or 14a with aldehydes or ketones leads to the isoxazole olefins 13 or the pyrazole olefins 18, respectively.