52068-17-4

Upstream product

• 23556-66-3 N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester 
• 2389-60-8 Z-Lys(Boc)-OH 
• 45309-32-8 N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester 
• 2389-48-2 N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride 
• 3017-32-1 (S)-methyl 2-amino-6-(tert-butoxycarbonylamino)hexanoate 

Downstream Products

• 87219-44-1 N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester 

Relevant academic research and scientific papers

Chloride-Assisted Peptide Macrocyclization

The role of the Cl- anion as a templating agent for the synthesis of cyclopeptides was assessed through the preparation of three new homocyclolysines and other six cyclic peptides by head-to-tail lactamization. Isolated yields of products obtai

MC-1. A "designer" surfactant engineered for peptide synthesis in water at room temperature

Aqueous micellar catalysis has previously been shown to be an enabling technology for green peptide synthesis. Nonetheless, in response to limitations associated with use of selected amino acids in peptide constructions, a new surfactant has been designed

LIGAND-TARGETED MOLECULES AND METHODS THEREOF

The present invention relates to ligand-targeted molecules and ligand drug conjugates (LDCs) comprising a ligand connected to a functional group, which is connected to a linker, which in turn is bonded to a drug. The LDCs of the present invention also comprise platinum coordination complex wherein the platinum is connected to the linker through monocarboxylato and O→Pt coordinate bonds. The present invention also relates to methods for preparing these ligand drug conjugates. The present invention further relates to methods for the treatment of tumours using the ligand drug conjugates of the present invention.