52072-95-4

Usage

InChI:InChI=1/C14H13ClN2O/c1-17(13-5-3-2-4-6-13)14(18)16-12-9-7-11(15)8-10-12/h2-10H,1H3,(H,16,18)

Upstream product

• 104-12-1 p-chlorphenylisocyanate 
• 100-61-8 N-methylaniline 
• 5023-88-1 4-chloro-N-((methylsulfonyl)oxy)benzimidoyl chloride 
• 3848-36-0 4-chlorobenzaldoxime 
• 132401-91-3 3-(4-chlorophenyl)-1,4,2-dioxazol-5-one 
• 591-50-4 iodobenzene 

Downstream Products

• 52073-00-4 N²-(p-Chlorphenyl)-N¹-methyl-N¹-phenylchlorformamidin 

Relevant academic research and scientific papers

2,2,2-Trifluroenthanol promoted synthesis of unsymmetrical ureas from dioxazolones and amines via tandem lossen rearrangement/condensation process

A 2,2,2-trifluroenthanol (TFE) promoted synthesis of unsymmetric ureas was described. This approach enabled the construction of a variety of ureas from the readily prepared and easy-to-handle dioxazolones and amines via tandem Lossen rearrangement/condensation process. The reaction featured mild conditions for the urea synthesis under metal-free conditions, which was successively applied in the scale-up synthesis of herbicides Monuro and Isoproturon.

Catalyst-Free Electrosynthesis of Benzimidazolones through Intramolecular Oxidative C?N Coupling

The electrochemical synthesis of N, N’-disubstituted benzimidazolones from ureas through an intramolecular anodic dehydrogenative N?H/C?H coupling has been developed. The reaction undergoes under the undivided electrolysis conditions and obviates the need for any catalysts and chemical oxidants. (Figure presented.).

Novel CRAC channel conditioning agent, and preparation method and applications thereof

The invention provides a novel CRAC (calcium release-activated calcium) channel conditioning agent, and a preparation method and applications thereof, and more specifically, the invention provides a compound represented by formula I, and the groups are defined in the patent specification. The invention also provides the preparation method of the compound represented by formula I, and applications of the compound as a CRAC channel conditioning agent.

One-pot synthesis of trisubstituted ureas from achloroaldoxime O-methanesulfonates and secondary amines

Trisubstituted ureas can be synthesized in a one-pot fashion from bench-stable a-chloroaldoxime Omethanesulfonates and secondary amines under mild reaction conditions. Two practical protocols have been developed to achieve various urea syntheses from both secondary aromatic amines and aliphatic amines.

INFRARED SPECTROSCOPIC AND CONFORMATIONAL STUDIES OF TRISUBSTITUTED UREAS CONTAINING CHLOROPHENYL GROUPS

The IR spectra, in the ν(N-H) region, of trisubstituted ureas R2UPhCl and RPhUPhCl containing a chlorophenyl group have been studied in order to examine the effects of the introduced chlorine atom.The out-trans-cis isomerism about the NH-CO rotational axis is discussed in reation to steric effect of the R2 group, Ph-Ph interaction and inter- and intra-molecular hydrogen bonding.In dilute solution, R2UPhCl exists in the trans or the out form, and RPhUPhCl in the cis form. o-Chlorophenyl derivatives show a monomeric ν(N-H) band at a wavenumber lower than that of the other derivatives and no associated ν(N-H) bands in concentrated or even in saturated solutions.Some of the derivatives are found to be in the same form in the solid state as in solution due to the retention of intra-molecular NH...Cl hydrogen bonding.