52083-48-4

Usage

Derivative

Purine

Type

Xanthine alkaloid

Medical use

Bronchodilator

Conditions treated

Asthma, chronic bronchitis, emphysema, apnea in premature infants

Mechanism of action

Relaxes muscles in the airways for easier breathing

Administration methods

Oral, intravenous injection

Metabolism

Liver

Role

Management of respiratory conditions, improved lung function

InChI:InChI=1/C11H14N4O4/c1-13-9-8(10(18)14(2)11(13)19)15(6-12-9)5-3-4-7(16)17/h6H,3-5H2,1-2H3,(H,16,17)/p-1

Upstream product

• 75058-89-8 ethyl 4-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)butanoate 

Relevant academic research and scientific papers

1H NMR study of the complexation of aromatic drugs with dimethylxanthine derivatives

With an aim of searching efficient interceptors of aromatic drugs, the self- and hetero-association of dimethylxanthine derivatives with different structures, selected according to Strategy 1 (variation of the position of methyl groups) and Strategy 2 (variation of the length of (CH2) nCOOH group), with aromatic drug molecules: Ethidium Bromide, Proflavine and Daunomycin, were studied using 1H NMR spectroscopy. It was found that the association proceeds in a form of stacking-type complexation and its energetics is relatively independent on the structure of the dimethylxanthines. However, on average, the dimethylxanthines possess higher hetero-association constant and, hence, higher interceptor ability as compared to the trimethylxanthine, Caffeine, used during the past two decades as a typical interceptor molecule.

Antigen, antiserum and immunoassay for theophylline

By injecting a host animal with a member of a particular group of antigens [a theophylline-(7)-alkanecarboxylic acid covalently bonded to an immunogenic carrier (IGC) via the carboxyl group], antibodies, advantageously employed in determining small amounts of theophylline in biological liquids by immunoassay methods, are obtained.