52086-52-9

Upstream product

• 52086-51-8 2-methyl-3-(o-tolyl)propanoic acid 
• 529-20-4 2-methylphenyl aldehyde 
• 95-47-6 o-xylene 
• 121611-29-8 C₁₁H₁₂O 
• 89-92-9 2-methylbenzyl bromide 
• 52086-50-7 diethyl 2-methyl-2-(2-methylbenzyl)malonate 
• 6619-57-4 diethyl 2-(2-methylbenzyl)-malonate 
• 5916-21-2 o-methyl-β,β-dimethylstyrene 

Downstream Products

• 52086-53-0 1-(γ-bromo-isobutyl)-2-methyl-benzene 
• 52086-54-1 3-Methyl-4-o-tolyl-butyronitrile 
• 52086-55-2 3-methyl-4-o-tolyl-butyric acid 

Relevant academic research and scientific papers

Highly pH-Dependent Chemoselective Transfer Hydrogenation of α,β-Unsaturated Aldehydes in Water

The pH-dependent selective Ir-catalyzed hydrogenation of α,β-unsaturated aldehydes was realized in water. Using HCOOH as the hydride donor at low pH, the unsaturated alcohol products were obtained exclusively, while the saturated alcohol products were formed preferentially by employing HCOONa as the hydride donor at high pH. A wide range of functional groups including electron-rich as well as electron-poor substituents on the aryl group of α,β-unsaturated aldehydes can be tolerated, affording the corresponding products in excellent yields with high TOF values. High selectivity and yields were also observed for α,β-unsaturated aldehydes with aliphatic substituents. Our mechanistic investigations indicate that the pH value is critical to the chemoselectivity.

Diastereoselective remote C-H activation by hydroboration

Hydroboration of tetrasubstituted or trisubstituted alkenes with BH 3 and subsequent thermolysis allows remote diastereoselective C-H activation of neighboring aryl rings. Tetrasubstituted and trisubstituted 1,1-diphenyl-ethylene derivatives undergo a highly stereoselective 1,2-rearrangement followed by remote C-H activation to lead, after oxidative workup, to a diol in which the relative stereochemistry of two stereocenters has been controlled. The mechanism of this remote activation has been studied and extended to related molecules that undergo this stereoselective C-H activation, namely alkenylbiphenyl systems or alkenes with only one phenyl ring, such as alkenylbenzenes. or bicyclic systems. We have shown that this reaction allows diastereoselective synthesis of molecules with up to three contiguous chiral centers.

Alcohols containing 2-methylphenyl or 2-methoxyphenyl groups, and fragrances containing same

The invention discloses compounds of the general formula STR1 in which R represents a methyl radical or a methoxy radical when R1 is a hydrogen atom; or R represents a methyl radical when R1 is a methyl radical. The compounds of the