52095-18-8

Usage

Uses

Used in Pharmaceutical Industry:
3,5-diMethyl-2-nitrobenzoic acid is used as a raw material for the synthesis of pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Dye Industry:
It serves as a precursor in the production of dyes, playing a crucial role in the creation of colorants for various applications.
Used in Organic Chemistry Research:
3,5-diMethyl-2-nitrobenzoic acid is utilized as a reagent in the field of organic chemistry, aiding in the advancement of chemical knowledge and the discovery of new compounds.
Used in Enzyme Kinetics Studies:
3,5-diMethyl-2-nitrobenzoic acid is employed in the study of enzyme kinetics, helping researchers understand the mechanisms and dynamics of enzymatic reactions.

Upstream product

• 499-06-9 3,5-dimethylbenzoic acid 
• 7697-37-2 nitric acid 
• 108-67-8 1,3,5-trimethyl-benzene 
• 14438-32-5 3,5-dimethylanthranilic acid 
• 603-71-4 nitromesitylene 

Downstream Products

• 686753-06-0 N-(2,2-dimethylpropyl)-3,5-dimethyl-2-nitrobenzamide 
• 95-68-1 2,4-Xylidine 
• 873388-89-7 (2-amino-3,5-dimethylphenyl)methanol 
• 1228047-60-6 1-(bromomethyl)-3,5-dimethyl-2-nitrobenzene 
• 54893-32-2 2-(3,5-dimethyl-2-nitrophenyl)acetonitrile 
• 198220-36-9 3,5-dimethyl-2-iodobenzoic acid 

Relevant academic research and scientific papers

Pendant Alkoxy Groups on N-Aryl Substitutions Drive the Efficiency of Imidazolylidene Catalysts for Homoenolate Annulation from Enal and Aldehyde

Hydrogen-transfer in the tetrahedral intermediate generated from an imidazolylidene catalyst and α,β-unsaturated aldehyde forms a conjugated Breslow intermediate. This is a critical step affecting the efficiency of the NHC-catalyzed γ-butyrolactone formation via homoenolate addition to aryl aldehydes. A novel type of imidazolylidene catalyst with pendant alkoxy groups on the ortho-N-aryl groups is described. Catalyst of this sort facilitates the formation of the conjugated Breslow intermediate. Studies of the rate constants for homoenolate annulation affording γ-butyrolactones, reveal that introduction of the oxygen atoms in the appropriate position of the N-aryl substituents can increase the efficiency of imidazolylidene catalysts. Structural and mechanistic studies revealed that pendant alkoxy groups can be located close to the proton of the tetrahedral intermediate, thereby facilitating the proton transfer.

Divergent Syntheses of Indoles and Quinolines Involving N1-C2-C3 Bond Formation through Two Distinct Pd Catalyses

Pd-catalyzed annulative couplings of 2-alkenylanilines with aldehydes using alcohols as both the solvent and hydrogen source have been developed. These domino processes allow divergent syntheses of two significant N-heterocycles, indoles and quinolines, from the same substrate by tuning reaction parameters, which seems to invoke two distinct mechanisms. The nature of the ligand and alcoholic solvent had a profound influence on the selectivity and efficiency of these protocols. Particularly noteworthy is that indole formation was achieved by overcoming two significant challenges, regioselective hydropalladation of alkenes and subsequent reactions between the resulting Csp3-Pd species and less reactive imines.

Method for synthetizing 2-amino-1, 3, 5-benzenetricarboxylic acid and application thereof for preparation of NH2-MOF-808

The invention belongs to the field of preparation and application of organic compounds and metal-organic framework compounds, and discloses a method for synthetizing 2-amino-1, 3, 5-benzenetricarboxylic acid and an application thereof for preparation of a

Twist does a twist to the reactivity: Stoichiometric and catalytic oxidations with twisted tetramethyl-IBX

The methyl groups in TetMe-IBX lower the activation energy corresponding to the rate-determining hypervalent twisting (theoretical calculations), and the steric relay between successive methyl groups twists the structure, which manifests in significant solubility in common organic solvents. Consequently, oxidations of alcohols and sulfides occur at room temperature in common organic solvents. In situ generation of the reactive TetMe-IBX from its precursor iodo-acid, i.e., 3,4,5,6-tetramethyl-2-iodobenzoic acid, in the presence of oxone as a co-oxidant facilitates the oxidation of diverse alcohols at room temperature.

Discovery, Modeling, and Human Pharmacokinetics of N-(2-Acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl) -thiophene-2-carboxamide (TBC3711), a Second Generation, ETA Selective, and Orally Bioavailable Endothelin Antagonist

Sitaxsentan (1) (Wu et al. J. Med. Chem. 1997, 40, 1690) is our first endothelin antagonist being evaluated in clinical trials. It has demonstrated biological effects in an acute hemodynamic study in CHF (Givertz et al. Circulation 2000, 101, 2922), an op