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1,2-Bis(2-phenylimidazo[1,2-a]pyridin-3-yl)disulfane is a sulfur-bridged imidazo[1,2-a]pyridine derivative synthesized through iodine-mediated oxidative homocoupling or metal-free oxidative dual C–H sulfenylation, using sodium sulfide or sulfur powder as the sulfur source. These methods provide efficient, scalable, and economical routes to form stable disulfane-linked heterocycles in high yields, with potential applications in biologically relevant compounds.

52095-68-8

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52095-68-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 52095-68-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,0,9 and 5 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 52095-68:
(7*5)+(6*2)+(5*0)+(4*9)+(3*5)+(2*6)+(1*8)=118
118 % 10 = 8
So 52095-68-8 is a valid CAS Registry Number.

52095-68-8Downstream Products

52095-68-8Relevant academic research and scientific papers

Solvent-Driven Iodine-Mediated Oxidative Strategies for the Synthesis of Bis(imidazo[1,2-a]pyridin-3-yl)sulfanes and Disulfanes

Shakoor, S. M. Abdul,Agarwal, Devesh S.,Khullar, Sadhika,Mandal, Sanjay K.,Sakhuja, Rajeev

, p. 3061 - 3068 (2017)

Two efficient iodine-mediated strategies, which are economical and one-pot, are described to access bis(imidazo[1,2-a]pyridin-3-yl)sulfanes and bis(imidazo[1,2-a]pyridin-3-yl)disulfanes in chloroform and acetic acid, respectively, by a direct oxidative homocoupling of imidazo-heterocycles using inexpensive sodium sulfide as a sulfur source. These strategies are scalable, and an array of substrates delivered their corresponding stable sulfur-bridged imidazo-heterocycles in excellent yields.

Oxidative dual C–H sulfenylation: A strategy for the synthesis of bis(imidazo[1,2-a]pyridin-3-yl)sulfanes under metal-free conditions using sulfur powder

Gan, Ziyu,Zhu, Xiaolong,Yan, Qiuli,Song, Xiuyan,Yang, Daoshan

, p. 1705 - 1708 (2021)

An efficient approach to sulfur-bridged imidazopyridines has been developed under metal-free conditions using inexpensive sulfur powder as the sulfur source. Most appealingly, the reaction can proceed smoothly without addition of any additives, ultimately decreasing the production of chemical waste. The inexpensive and green method should provide a useful strategy for constructing a library of novel and biological interesting heteroaromatic sulfides.

Metal-Free Thiolation of Imidazopyridines with Functionalized Haloalkanes Using Elemental Sulfur

Zhang, Jun-Rong,Zhan, Ling-Zhi,Wei, Liang,Ning, Yun-Yun,Zhong, Xiao-Lin,Lai, Jing-Xiong,Xu, Li,Tang, Ri-Yuan

, p. 533 - 543 (2018/01/27)

The assembly of two functional molecules via a sulfur linking atom allows an access to a diverse array of thioether-containing compounds. Herein, we disclose a metal-free thiolation of imidazopyridines with a variety of functionalized haloalkanes using elemental sulfur. (Figure presented.).

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