52103-13-6

Downstream Products

• 110188-95-9 [(1R,4S,5R,6R)-4-((S)-1,5-Dimethyl-hex-4-enyl)-6-[(Z)-4-(tetrahydro-pyran-2-yloxy)-but-1-enyl]-5-(tetrahydro-pyran-2-yloxymethyl)-cyclohex-2-enyl]-methanol 

Relevant academic research and scientific papers

7-Oxabicyclo(2.2.1)heptane hydroxamic acid derivatives useful as antiinflammatory, antiasthma and antipsoriatic agents

7-Oxabicyclo(2.2.1)heptane hydroxamic acid derivatives are disclosed having the general formula STR1 wherein R1 is hydrogen, lower alkyl, aryl, aralkyl or alkenyl; R2 is hydrogen, lower alkyl, alkanoyl or aroyl; R3 is lower alkyl, alkenyl or alkynyl; A is --CH2 --CH=CH-- or a single bond; and n is an integer from 0 to 9, with the proviso that when A is a single bond, n is an integer from 1 to 9; and including all stereoisomers and pharmaceutically acceptable salts thereof. These new compounds have been found to simultaneously inhibit the arachidonic acid enzymes cyclooxygenase and 5-lipoxygenase and are therefore useful as antiinflammatory, antiasthma and antipsoriatic agents.