521058-99-1Relevant academic research and scientific papers
5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: Molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile
Sakya, Subas M.,Hou, Xinjun,Minich, Martha L.,Rast, Bryson,Shavnya, Andrei,DeMello, Kristin M.L.,Cheng, Hengmiao,Li, Jin,Jaynes, Burton H.,Mann, Donald W.,Petras, Carol F.,Seibel, Scott B.,Haven, Michelle L.
, p. 1067 - 1072 (2007)
The structure-activity relationship toward canine COX-1 and COX-2 in vitro whole blood activity of 4-hydrogen versus 4-cyano substituted 5-aryl or 5-heteroatom substituted N-phenyl versus N-2-pyridyl sulfone pyrazoles is discussed. The differences between
