521086-80-6Relevant academic research and scientific papers
Copper-catalyzed preparation of ketones bearing a stereogenic center in α position
Soorukram, Darunee,Knochel, Paul
, p. 3686 - 3689 (2008/02/12)
A highly enantioselective synthesis of α-alkylated and -arylated ketones can be achieved by using a reaction sequence consisting of a stereoselective anti-SN2′ allylic substitution in the presence of CuCN·2LiCl following by the oxidation of an intermediate cycloalkenyl lithium species using (Me3SiO)2 or (MeO) 3B/NaBO3·4H2O. (Chemical Equation Presented).
Highly anti-selective SN2′ substitutions of chiral cyclic 2-lodo-allylic alcohol derivatives with mixed zinc-copper reagents
Calaza, M. Isabel,Hupe, Eike,Knochel, Paul
, p. 1059 - 1061 (2007/10/03)
(Figure presented) Functionalized allylic electrophilic reagents such as chiral 2-iodo-1-cyclohexenyl and -cyclopentenyl phosphates undergo highly stereoselective anti-SN2′-allylic substitution reactions with a wide range of organozinc reagents
