52109-67-8Relevant articles and documents
Substituent effect of 2,3-dicyanopyrazine dyes on solid-state fluorescence
Horiguchi, Emi,Matsumoto, Shinya,Funabiki, Kazumasa,Matsui, Masaki
, p. 799 - 805 (2006)
Some pyrazine dyes based on the same chromophoric system with different steric nature were synthesized to evaluate the correlation between solid-state fluorescence and molecular arrangement. It was confirmed that the solid-state fluorescence is significan
Clean and green approach for one-pot synthesis of pyrazines from Eth-ylenediamine and 1,2-diketone or its analogues under neat reaction condition
Ghosh, Pranab,Chakraborty, Rakesh Ranjan
, p. 566 - 570 (2017/09/29)
Background: Compounds having N-heterocyclic moieties are of huge importance in the field of agrochemical, pharmaceutical, biological, fragrances, etc. Due to a lot of applications associated with pyrazine moieties, their synthesis has always been important for organic chemists. Method: Surfeit synthetic methodologies are documented in literature. Most of the methodologies used expensive solvents, harmful metal catalyst and all suffer from rigorous work-up procedures. An efficient, environmentally benign methodology, needs to be developed. We mixed ethylenediamine (2mmol) with 1, 2-diketone(1mmol), later, α-hydroxy ketone and α-bromo ketone on magnetic stirrer at room temperature under neat reaction condition for 5 to 10 hrs. Results: After purification by column chromatography using silica gel(60-120 mesh) and pet-ether, et-hylacetate mixture as eluent, we achieved pyrazine derivatives from moderate to high yield. Conclusio n: Efficient and clean procedure for one-pot preparation of pyrazines from ethylenediamine and 1, 2-diketones or with α-hydroxy ketone or with α-bromo ketone has been carried out under neat reaction condition at room temperature. Environmentally benign process furnishing moderate to excellent yields of the product and simple work-up giving pure products are special features of this reaction.
