52109-85-0

Upstream product

• 527-69-5 2-furancarbonyl chloride 
• 99-09-2 3-nitro-aniline 
• 1026046-13-8 2-furanoyl sulfonate 
• 88-14-2 2-furanoic acid 

Downstream Products

• 312915-74-5 C₁₈H₁₄N₂O₃ 
• 640759-13-3 3,4,5-trimethoxy-N-(3-(2-furanoylcarboxamido)phenylcarbamothioyl)benzamide 
• 247109-35-9 furan-2-carboxylic acid-(3-amino-anilide) 

Relevant academic research and scientific papers

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors that avoid the closely related TASK-3 channel has been challenging. In this study, a series of bis-amide derived compounds were found to demonstrate improved TASK-1 selectivity over TASK-3 compared to reported inhibitors. Optimization of a marginally selective hit led to analog 35 which displays a TASK-1 IC 50 = 16 nM with 62-fold selectivity over TASK-3 in an orthogonal electrophysiology assay.

Determination of aromaticity indices of thiophene and furan by nuclear magnetic resonance spectroscopic analysis of their anilides

A series of m- and p-substituted anilides of benzoic acid, 2-thienoic acid, and 2-furoic acid were prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shifts of proton and carbon signals of the acyl aromatic rings and the Hammett σ. Plots of the chemical shift values of the carbonyl carbons of the benzanilides against those of the 2-thienamides and 2-furamides gave an excellent correlation and the values of the slopes are 0.79 and 0.52, respectively, in dimethyl sulfoxide-d6. The slopes could be considered as a set of aromaticity index.

Facile and effective synthesis of N-aryl-2-furancarboxamides derivatives under the condition of phase transfer catalysis

A convenient one-pot procedure is reported for the preparation of N- aryl-2-furancarboxamide derivatives. 2-Furoic acid is activated by benzenesulfonyl chloride under the condition of solid-liquid phase transfer catalysis using solid potassium carbonate a