5211-52-9Relevant academic research and scientific papers
Amberlyst-15 catalyzed Cbz protection of amines under solvent-free conditions
Bora, Pranja P.,Vanlaldinpuia, Khiangte,Rokhum, Lalthazuala,Bez, Ghanashyam
experimental part, p. 2674 - 2683 (2011/08/22)
Amberlyst-15 can effectively catalyze Cbz protection of aliphatic and aromatic amines within 10-15 min under solvent-free conditions. The catalyst can be used repeatedly without loss of activity, and the reaction requires no workup and gives excellent yields. Taylor & Francis Group, LLC.
An excellent method for Cbz-protection of amines
Vanlaldinpuia, Khiangte,Sema, H. Atoholi,Rokhum, Lalthazuala,Bez, Ghanashyam
experimental part, p. 228 - 229 (2010/08/20)
Cbz-protection of aliphatic and aromatic amines can be accomplished with benzylchloroformate using a catalytic amount of dodecatungstophosphoric acid hydrate (0.05 equiv). The reaction is simple, fast, does not require aqueous work-up and gives excellent yields.
