52112-66-0

Basic information

• Product Name: 6-BROMOBENZOXAZOLE
• Synonyms: 6-BROMOBENZO[D]OXAZOLE;6-Bromo-2-benzoxazolamine;2-Amino-6-bromobenzoxazole;2-Benzoxazolamine, 6-bromo-;Nsc26185;Benzoxazole,2-amino-6-bromo- (7CI);6-Brom-benzoxazol-2-ylamin;2-amino-6-bromo-benzoxazol
• CAS NO: 52112-66-0
• Molecular Formula: C₇H₅BrN₂O
• Molecular Weight: 198.02
• Product Categories: Miscellaneous
• Mol File: 52112-66-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 340.4 °C at 760 mmHg
• Flash Point: 159.7 °C
• Appearance: /
• Density: 1.6569 (rough estimate)
• Refractive Index: 1.6500 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.08±0.30(Predicted)
• CAS DataBase Reference: 6-BROMOBENZOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMOBENZOXAZOLE(52112-66-0)
• EPA Substance Registry System: 6-BROMOBENZOXAZOLE(52112-66-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 52112-66-0(Hazardous Substances Data)

Usage

General Description

6-Bromobenzoxazole is a heterocyclic organic compound characterized by a benzene ring with attached bromine and oxazole units. Oxazole is a five-membered ring composed of one oxygen atom, one nitrogen atom, and three carbon atoms. 6-Bromobenzoxazole is used as a building block in the synthesis of various organic substances, including those used in medicinal chemistry research. Its physical properties, safety protocols, and methods of storage and disposal should be appropriately observed due to its potentially reactive and hazardous nature.

Upstream product

• 1404480-07-4 C₇H₇BrN₂OS 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 38191-34-3 2-amino-5-bromophenol 
• 27684-84-0 5-bromo-2-nitrophenol 
• 591-20-8 3-Bromophenol 
• 1967-25-5 4-bromophenylurea 
• 1520-26-9 2-hydroxyphenylthiourea 
• 4570-41-6 1,3-benzoxazol-2-amine 

Downstream Products

• 6885-69-4 [4-(6-bromo-benzooxazol-2-ylsulfamoyl)-phenyl]-carbamic acid methyl ester 
• 13895-23-3 1-(6-bromo-benzooxazol-2-yl)-3-phenyl-thiourea 
• 14721-89-2 1-(6-bromo-benzooxazol-2-yl)-3-(4-ethoxy-phenyl)-thiourea 
• 1260091-04-0 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazol-2-amine 
• 1430720-29-8 C₁₄H₁₂N₂O₂ 
• 1313488-93-5 N-(5-(2-aminobenzo[d]oxazol-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide 
• 6822-81-7 4-amino-N-(6-bromo-benzooxazol-2-yl)-benzenesulfonamide 
• 19932-85-5 6-bromobenzo[d]oxazol-2(3H)-one 

Relevant articles and documents

A facile synthesis of 2-aminobenzoxazoles and 2-aminobenzimidazoles using N -cyano- N -phenyl- P -toluenesulfonamide (NCTS) as an efficient electrophilic cyanating agent

A facile synthesis of 2-aminobenzoxazole and 2-aminobenzimidazole derivatives employing a nonhazardous electrophilic cyanating agent: N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) with various substituted 2-aminophenols and benzene-1,2-diamine derivatives in the presence of lithium hexamethyldisilazide (LiHMDS) is described. This novel protocol boasts operational simplicity, shorter reaction time, and simple workup.

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase a and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth. The present invention also provides a pharmaceutical kit effective for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject.

Poly (ethylene glycol)-bound sulphonic acid as a novel catalyst for synthesis of benzoxazoles

ABSTRACT Ahighly efficient, simple and rapid method for the preparation of various 2-aminobenzoxazoles and other benzoxazole derivatives using a catalytic amount of poly (ethylene glycol)-bound sulphonic acid (PEG-SO3H) is described. PEG-SO3H is found to be economical and reusable catalyst with low catalytic loading. The percentage yield was found to be satisfactory, experimental set-up and purification of final products is facile and easy. GRAPHICAL ABSTRACT.