52112-82-0

Basic information

• Product Name: Thiourea, (6-methyl-2-benzothiazolyl)- (9CI)
• Synonyms: Thiourea, (6-methyl-2-benzothiazolyl)- (9CI)
• CAS NO: 52112-82-0
• Molecular Formula: C₉H₉N₃S₂
• Molecular Weight: 223.31786
• Product Categories: BENZOTHIAZOLE
• Mol File: 52112-82-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thiourea, (6-methyl-2-benzothiazolyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, (6-methyl-2-benzothiazolyl)- (9CI)(52112-82-0)
• EPA Substance Registry System: Thiourea, (6-methyl-2-benzothiazolyl)- (9CI)(52112-82-0)

Safety Data

• Hazardous Substances Data: 52112-82-0(Hazardous Substances Data)

Upstream product

• 2536-91-6 6-methylbenzothiazol-2-ylamine 
• 52112-81-9 1-<2-(6-methyl)benzothiazolyl>-3-benzoylthiocarbamide 
• 92987-73-0 N-<2-(6-methyl)benzothiazolyl>cyanamide 
• 1147550-11-5 ammonium thiocyanate 
• 56896-76-5 6-methyl-benzothiazol-2-ylamine; hydrochloride 

Downstream Products

• 59362-03-7 5-(4-dimethylamino-benzylidene)-3-(6-methyl-benzothiazol-2-yl)-2-thioxo-imidazolidin-4-one 
• 56160-14-6 5-(2-hydroxy-benzylidene)-2-(6-methyl-benzothiazol-2-ylamino)-thiazol-4-one 
• 56160-10-2 5-(2-chloro-benzylidene)-2-(6-methyl-benzothiazol-2-ylamino)-thiazol-4-one 
• 56160-11-3 5-(4-bromo-benzylidene)-2-(6-methyl-benzothiazol-2-ylamino)-thiazol-4-one 
• 56160-08-8 5-benzylidene-2-(6-methyl-benzothiazol-2-ylamino)-thiazol-4-one 
• 89402-85-7 [4-(4-Chloro-phenyl)-2-(6-methyl-benzothiazol-2-ylamino)-thiazol-5-yl]-acetic acid 
• 89402-84-6 [2-(6-Methyl-benzothiazol-2-ylamino)-4-phenyl-thiazol-5-yl]-acetic acid 
• 89402-86-8 [4-(4-Methoxy-phenyl)-2-(6-methyl-benzothiazol-2-ylamino)-thiazol-5-yl]-acetic acid 
• 64378-09-2 [4-(4-bromo-phenyl)-thiazol-2-yl]-(6-methyl-benzothiazol-2-yl)-amine 
• 64378-08-1 [4-(4-chloro-phenyl)-thiazol-2-yl]-(6-methyl-benzothiazol-2-yl)-amine 
• 64378-07-0 (6-methyl-benzothiazol-2-yl)-(4-p-tolyl-thiazol-2-yl)-amine 
• 64378-06-9 (6-methyl-benzothiazol-2-yl)-(4-phenyl-thiazol-2-yl)-amine 
• 92969-21-6 2-benzyl-1-(6-methyl-benzothiazol-2-yl)-isothiourea 

Relevant articles and documents

Benzothiazole thiourea derivatives as anticancer agents: Design, synthesis, and biological screening

In a systematic effort to identify a potent anticancer agent, we synthesized benzothiazole thiourea derivatives and examined their cytotoxic activity against five different human and animal cancer cell lines. Benzothiazolylthiocarbamides have been prepared in excellent yields by reaction of substituted 2-amino benzothiazoles with carbon disulfide and dimethyl sulfate followed by their ammonolysis. Cytotoxicity of the four compounds were screened for antitumor activity against human breast cancer cells (MCF-7), human cervix epithelial carcinoma (HeLa), human colon cancer cell line (HT-29), human leukemia cell line (K-562), and mouse neuroblastoma cell line (Neuro-2a) using cisplatin as a reference by MTT assay. Our results presented herein provide experimental evidence that benzothiazolylthiocarbamides induce apoptosis in cancer cell lines. According to flow cytometry results, treatment of HT-29 cells with 1-(6-ethoxy-1,3-benzothiazol- 2-yl)thiourea produced a large population of apoptotic cell (79.45%), which was 1.2-fold higher than that produced by cisplatin (65.28%) at the same concentration.

Synthesis and biological activity of some 3-arylimino-5-[2-(6-methyl)benzothiazolyl]imino-1,2,4-dithiazolidines

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Studies in the synthesis of thiazolidinones. Part II. 5 Benzal derivatives of 2 (substituted benzothiazole 2 yl imino) 4 thiazolidinones and their brominated products

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