52112-82-0Relevant articles and documents
Benzothiazole thiourea derivatives as anticancer agents: Design, synthesis, and biological screening
Eshkil, Fatemeh,Eshghi, Hossein,Saljooghi, Amir. Sh.,Bakavoli, Mehdi,Rahimizadeh, Mohammad
, p. 576 - 582 (2017/09/27)
In a systematic effort to identify a potent anticancer agent, we synthesized benzothiazole thiourea derivatives and examined their cytotoxic activity against five different human and animal cancer cell lines. Benzothiazolylthiocarbamides have been prepared in excellent yields by reaction of substituted 2-amino benzothiazoles with carbon disulfide and dimethyl sulfate followed by their ammonolysis. Cytotoxicity of the four compounds were screened for antitumor activity against human breast cancer cells (MCF-7), human cervix epithelial carcinoma (HeLa), human colon cancer cell line (HT-29), human leukemia cell line (K-562), and mouse neuroblastoma cell line (Neuro-2a) using cisplatin as a reference by MTT assay. Our results presented herein provide experimental evidence that benzothiazolylthiocarbamides induce apoptosis in cancer cell lines. According to flow cytometry results, treatment of HT-29 cells with 1-(6-ethoxy-1,3-benzothiazol- 2-yl)thiourea produced a large population of apoptotic cell (79.45%), which was 1.2-fold higher than that produced by cisplatin (65.28%) at the same concentration.
SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION
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Paragraph 0135; 0136; 0137, (2013/04/24)
Pharmaceutical compositions of the invention are presented which comprise substiuted aminothiazoles derivatives. The substiuted aminothiazoles derivatives have a disease-modifying action in the treatment of diseases associated with unregulated cell growth. Such diseases include cancers such as hepatocellular carcinoma, and viral infections from a hepatitis virus.
Synthesis of 5-Substituted-benzothiazolylimino-3-arylimino-1,2,4-dithiazolidines
Singh, A. P.,Bhattacharya, A.,Verma, V. K.
, p. 223 - 225 (2007/10/02)
A simple and convenient synthesis of 5--imino-3-arylimino-1,2,4-dithiazolodines (7a-d) has been achieved by the oxidation and cyclisation of the corresponding 1--5-aryl-2-S-allyliso-2,4-dithiobiurets (6a-d), which in turn were prepared by the condensation of 1--2-S-allylisothiocarbamide (5) with appropriate aryl isothiocyanate.The compounds have been characterised by their synthesis through alternative routes, elemental analyses, and also by ir and pmr spectra.
