52116-51-5

Usage

InChI:InChI=1/C12H24N2O6/c13-5-3-1-2-4-8(16)14-12-11(19)10(18)9(17)7(6-15)20-12/h7,9-12,15,17-19H,1-6,13H2,(H,14,16)/t7-,9+,10+,11-,12?/m1/s1

Upstream product

• 6404-29-1 6-(tert-butoxycarbonylamino)hexanoic acid 
• 13992-25-1 1-azido-1-deoxy-β-D-glucopyranoside tetraacetate 
• 353264-31-0 C₁₇H₂₈NO₉P 
• 1243271-51-3 N-(6-azidohexanoyl)-β-D-glucopyranosylamine 
• 1243271-25-1 N-(6-azidohexanoyl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine 
• 1243271-22-8 N-(6-bromohexanoyl)-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamine 
• 1947-00-8 6-(benzyloxycarbonylamino)hexanoic acid 
• 4644-75-1 6-benzyloxycarbonylaminocapronoyl chloride 
• 7388-99-0 β-D-mannopyranosyl amine 
• 53784-29-5 2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl azide 
• 41355-50-4 1-amino-2,3,4,6-tetra-O-acetyl-β-D-mannopyranosyl 
• 83-87-4 D-Mannose pentaacetate 
• 14152-97-7 2,3,4,6-tetra-O-Acetyl-β-D-galactopyranosyl isothiocyanate 
• 74761-70-9 2,3,4,6-tetra-O-acetyl-N-<(6-benzyloxycarbonylamino)hexanoyl>-β-D-mannopyranosylamine 

Relevant academic research and scientific papers

Tethered derivatives of d-glucose and pentacyclic triterpenes for homo/heterobivalent inhibition of glycogen phosphorylase

Propargyl esters of the C-28 carboxylic acids of pentacyclic triterpenes (oleanolic, ursolic, and maslinic acids) were coupled with 2,3,4,6-tetra-O- acetyl-β-d-glucopyranosyl azide as well as N-(ω-azido-[C-2, C-6, and C-11]alkanoyl)-β-d-glucopyranosylamines under conditions of copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) to give tethered d-glucose-triterpene heteroconjugates. The O-acetyl protecting groups were removed by base-catalyzed hydrolysis. N-(ω-Azido-[C-2, C-6, C-11, and C-16]alkanoyl)-β-d-glucopyranosylamines were also tethered by 1,7-octadiyne under CuAAC conditions to furnish d-glucose homoconjugates. O-Deacetylation was carried out by the Zemplen protocol. The new compounds were assayed against rabbit muscle glycogen phosphorylase (RMGP) a or b enzymes. Some of the heteroconjugates inhibited the enzyme in the low micromolar range (IC 50 values 40-70 μM), while the homoconjugates proved inefficient as inhibitors.

Synthesis and characterisation of poly (L-lactic acid) galactosyl derivatives; access to functionalised microspheres

A new series of galactosyl-derived polymers has been used for the preparation of microspheres. The strategy is based on the modification of the terminal carboxylic group L-PLA (73.000) by coupling to a galactosyl antenna in the presence of the peptide coupling agents: DCC/HOBT. The degree of functionalisation varies between 60 and 70%, and antenna density between 1.74 and 2.78. The characterisations of the new products were carried out using 1H NMR, gel permeation chromatography, and acid base titration; the size of the functionalised microspheres was determined to be 210-270 μm by DLS. (C) 2000 Elsevier Science Ltd.

PURIFICATION AND PROPERTIES OF A β-D-MANNOSIDE MANNOHYDROLASE FROM GUAR

A β-D-mannoside mannohydrolase enzyme has been purified to homogeneity from germinated guar-seeds.Difficulties associated with the extraction and purification appeared to be due to an interaction of the enzyme with other protein material.The purified enzyme hydrolysed various natural and synthetic substrates, including β-D-manno-oligosaccharides and reduced β-D-manno-oligosaccharides of degree of polymerisation 2 to 6, as well as p-nitrophenyl, naphthyl, and methylumbelliferyl β-D-mannopyranosides.The preferred, natural substrate was β-D-mannopentaose, which was hydrolysed at twice the rate of β-D-mannotetraose and five times the rate of β-D-mannotriose.This result, together with the observation that α-D-mannose is released on hydrolysis, indicates that the enzyme is an exo-β-D-mannanase.