52120-67-9

Upstream product

• 39832-47-8 1-(thiazol-2-yloxy)-2,3-epoxypropane 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 39832-45-6 3-thiazol-2-yloxy-propane-1,2-diol 

Relevant academic research and scientific papers

THIAZOLE CARDIOVASCULAR AGENTS

1-Amino-3-2-thiazoloxy!-2-propanol and substituted 1-amino derivatives thereof; 3-2-thiazoloxy!-1,2-epoxypropane 5-thiazol-2-oxymethylene!-oxazolidine and/or N-substituted and/or 2-substituted oxazolidine, derivatives thereof and methods of preparing such compounds. The above 1-amino-3-2-thiazoloxy!-2-propanol and derivatives exhibit . beta.-adrenergic stimulating cardiovascular activity and are useful for the treatment of abnormal heart conditions in mammals. The above 3-2-thiazoloxy!-1,2-epoxypropane and derivatives are useful as intermediates for the aforementioned cardiovascular agents. The 5-thiazol-2-oxymethylene!-oxazolidine and derivatives are intermediates for aforementioned cardiovascular agents. The 1-amino-3-2-thiazoloxy!-2-propanol and derivatives can be prepared by base or acid hydrolysis of the corresponding 5-thiazol-2-oxymethylene!-oxazolidine or derivatives; or by treatment of the corresponding 3-2-thiazoloxy!-2,3-epoxypropane or derivative with the desired amine or amino-derivative.