521286-38-4

Usage

Uses

Used in Pharmaceutical Industry:
Norvaline, N-[(1,1-dimethylethoxy)carbonyl]-(9CI) is used as a key intermediate in the synthesis of 4-phenylpiperidine-substituted amino acid derivatives, particularly Valine amides. These derivatives serve as modulators of chemokine receptor activity, which can be utilized in the development of treatments for inflammatory and autoimmune diseases. Norvaline,N-[(1,1-dimethylethoxy)carbonyl]-(9CI)'s unique structure allows for the creation of novel therapeutic agents that can target specific pathways involved in these conditions, potentially leading to more effective and targeted treatments.

Upstream product

• 660-88-8 5-aminopentanoic acid 
• 760-78-1 2-aminopentanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 135263-89-7 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (S)-2-<(tert-butoxycarbonyl)amino>pentanoate 
• 145308-95-8 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (R)-2-<(tert-butoxycarbonyl)amino>pentanoate 
• 367258-46-6 {1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-butyl}-carbamic acid tert-butyl ester 
• 946581-22-2 C₂₇H₂₉ClN₂O₂ 
• 946581-17-5 C₂₄H₂₉ClN₂O₂ 
• 946581-16-4 C₂₃H₂₇ClN₂O₂ 

Relevant academic research and scientific papers

Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection

Due to the increased morbidity and mortality by fungal infections and the emergence of severe antifungal resistance, there is an urgent need for new antifungal agents. Here, we screened for antifungal activity in our in-house library through the minimum inhibitory concentration test and derived two hit compounds with moderate antifungal activities. The hit compounds' antifungal activities and drug-like properties were optimized by substituting various aryl ring, alkyl chain, and methyl groups. Among the optimized compounds, 22h was the most promising candidate with good drug-like properties and exhibited potent fast-acting fungicidal antifungal effects against various fungal pathogens and synergistic antifungal activities with some known antifungal drugs. Additionally, 22h was further confirmed to disturb fungal cell wall integrity by activating multiple cell wall integrity pathways. Furthermore, 22h exerted significant antifungal efficacy in both the subcutaneous infection mouse model and ex vivo human nail infection model.

FUNCTIONAL DERIVATIVE COMPOUNDS OF ALANINE AND PROLINE AMINO ACIDS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to novel functional derivatives of alanine and proline amino acids. The compounds of the present invention were confirmed to have a very superior antifungal or fungicidal effect. In addition, the compounds of the present inve

RENIN INHIBITING COMPOUNDS

Compounds which are amino acid derivatives and have the formula STR1 in which R 1 is hydrogen or methyl, R 2 is ethyl, propyl or imidazol-4-yl, R 3 is isobutyl, cyclohexylmethyl or benzyl, and A is defined as herein are useful as renin inhibitors.