521286-38-4

Basic information

• Product Name: Norvaline,N-[(1,1-dimethylethoxy)carbonyl]-(9CI)
• Synonyms: Norvaline,N-[(1,1-dimethylethoxy)carbonyl]-(9CI);rac Boc-norvaline;2-tert-ButoxycarbonylaMinopentanoic Acid;N-[(1,1-DiMethylethoxy)carbonyl]norvaline;Boc-DL-norvaline;2-([(TERT-BUTOXY)CARBONYL]AMINO)PENTANOIC ACID(WXG01935)
• CAS NO: 521286-38-4
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 217.26216
• Product Categories: N-BOC;Aliphatics;Amino Acids & Derivatives;Intermediates
• Mol File: 521286-38-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Norvaline,N-[(1,1-dimethylethoxy)carbonyl]-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Norvaline,N-[(1,1-dimethylethoxy)carbonyl]-(9CI)(521286-38-4)
• EPA Substance Registry System: Norvaline,N-[(1,1-dimethylethoxy)carbonyl]-(9CI)(521286-38-4)

Safety Data

• Hazardous Substances Data: 521286-38-4(Hazardous Substances Data)

Usage

Uses

rac-Boc Norvaline is used in the preparation of 4-phenylpiperidine-substituted amino acid derivatives, particularly Valine amides, as modulators of chemokine receptor activity and their use in the treatment of inflammatory and autoimmune diseases.

Upstream product

• 760-78-1 2-aminopentanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 660-88-8 5-aminopentanoic acid 

Downstream Products

• 946581-22-2 C₂₇H₂₉ClN₂O₂ 
• 946581-17-5 C₂₄H₂₉ClN₂O₂ 
• 946581-16-4 C₂₃H₂₇ClN₂O₂ 
• 946656-74-2 2-amino-1-(4-(4-chlorophenyl)piperidin-1-yl)pentan-1-one 
• 1394017-67-4 N-(1-(4-chlorophenyl)-1-oxopentan-2-yl)benzamide 
• 1394017-95-8 2-amino-1-(4-chlorophenyl)pentan-1-one 

Relevant articles and documents

Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection

Due to the increased morbidity and mortality by fungal infections and the emergence of severe antifungal resistance, there is an urgent need for new antifungal agents. Here, we screened for antifungal activity in our in-house library through the minimum inhibitory concentration test and derived two hit compounds with moderate antifungal activities. The hit compounds' antifungal activities and drug-like properties were optimized by substituting various aryl ring, alkyl chain, and methyl groups. Among the optimized compounds, 22h was the most promising candidate with good drug-like properties and exhibited potent fast-acting fungicidal antifungal effects against various fungal pathogens and synergistic antifungal activities with some known antifungal drugs. Additionally, 22h was further confirmed to disturb fungal cell wall integrity by activating multiple cell wall integrity pathways. Furthermore, 22h exerted significant antifungal efficacy in both the subcutaneous infection mouse model and ex vivo human nail infection model.

RENIN INHIBITING COMPOUNDS

Compounds which are amino acid derivatives and have the formula STR1 in which R 1 is hydrogen or methyl, R 2 is ethyl, propyl or imidazol-4-yl, R 3 is isobutyl, cyclohexylmethyl or benzyl, and A is defined as herein are useful as renin inhibitors.