521286-75-9

Basic information

• Product Name: Methyl 4-chloro-9H-pyriMido[4,5-b]indole-6-carboxylate
• Synonyms: Methyl 4-chloro-9H-pyriMido[4,5-b]indole-6-carboxylate;4-Chloro-1H-pyrimido[4,5-b]indole-6-carboxylic acid methyl ester;4-Chloro-9H-pyrimido[4,5-b]indole-6-carboxylic acid methyl ester;4-Chloro-9H-1,3,9-triaza-fluorene-6-carboxylic acid Methyl ester
• CAS NO: 521286-75-9
• Molecular Formula: 12H8ClN3O2
• Molecular Weight: 261.66382
• Mol File: 521286-75-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.518
• CAS DataBase Reference: Methyl 4-chloro-9H-pyriMido[4,5-b]indole-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-chloro-9H-pyriMido[4,5-b]indole-6-carboxylate(521286-75-9)
• EPA Substance Registry System: Methyl 4-chloro-9H-pyriMido[4,5-b]indole-6-carboxylate(521286-75-9)

Safety Data

• Hazardous Substances Data: 521286-75-9(Hazardous Substances Data)

Upstream product

• 521286-74-8 methyl 4-hydroxy-(9H)-pyrimido[4,5-b]indole-6-carboxylate 

Relevant articles and documents

4-PHENYL-PYRIMIDO [4,5-B] INDOLE DERIVATIVES

The present invention relates to 4-phenyl-pyrimido[4,5-b]indoles which are useful as an active ingredient of pharmaceutical preparations. The 4-phenyl-pyrimido[4,5-b]indoles of the present invention have MKK7 and MKK4 inhibitory activity, and can be used for the prophylaxis and treatment of diseases associated with MKK7 and MKK4 activity.Such diseases include, inflammatory and immunoregulatory disorders and diseases such as asthma, atopic dermatitis, rhinitis, allergic rhinitis, allergic diseases, COPD, septic shock, arthritis, joint diseases and myocardial injuries, as well as autoimmune pathologies such as rheumatoid arthritis, Grave's disease, and atherosclerosis as well as cancer.The compounds of the present invention are also useful for treatment of ischemia, myocardial injury, pulmonary hypertension, renal failure, Huntington's chorea and cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and focal ischemia.