52129-61-0

Usage

Uses

1-(4-HYDROXY-3,5-DINITROPHENYL)ETHANONE is used as an intermediate compound in the synthesis of various organic compounds, particularly those with antimicrobial properties.
Used in Pharmaceutical Industry:
1-(4-HYDROXY-3,5-DINITROPHENYL)ETHANONE is used as a key intermediate for the synthesis of antimicrobial agents. Its chemical structure allows for the development of compounds that can effectively target and inhibit the growth of harmful microorganisms, such as bacteria and fungi.
Used in Chemical Synthesis:
1-(4-HYDROXY-3,5-DINITROPHENYL)ETHANONE serves as a versatile building block in the synthesis of a wide range of chemical compounds. Its functional groups can be further modified or reacted with other molecules to create new compounds with specific properties and applications.

Preparation

Preparation by nitration of 4-hydroxyacetophenone with potassium nitrate in concentrated sulfuric acid at 5–10°.

InChI:InChI=1/C8H6N2O6/c1-4(11)5-2-6(9(13)14)8(12)7(3-5)10(15)16/h2-3,12H,1H3

Upstream product

• 6322-56-1 4'-hydroxy-3'-nitroacetophenone 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 102882-63-3 2-(4-acetyl-2,6-dinitro-phenoxy)-1-phenyl-ethanone 
• 124270-56-0 1,3-bis-benzoylamino-2-benzoyloxy-5-(1-hydroxy-ethyl)-benzene 
• 1319203-48-9 (2E)-3-(2-bromophenyl)-1-(4-hydroxy-3,5-dinitrophenyl)propenone 
• 1319203-49-0 (2E)-3-(4-bromophenyl)-1-(4-hydroxy-3,5-dinitrophenyl)propenone 
• 1319203-44-5 (2E)-1-(4-hydroxy-3,5-dinitrophenyl)-3-(4-methoxyphenyl)propenone 
• 3844-88-0 (2E)-1-(4-hydroxy-3,5-dinitrophenyl)-3-(4-hydroxyphenyl)propenone 
• 1319203-46-7 (2E)-1-(4-hydroxy-3,5-dinitrophenyl)-3-(phenyl)propenone 
• 1319203-50-3 (2E)-3-(2-chlorophenyl)-1-(4-hydroxy-3,5-dinitrophenyl)propenone 
• 1319203-51-4 (2E)-3-(4-chlorophenyl)-1-(4-hydroxy-3,5-dinitrophenyl)propenone 
• 1319203-53-6 (2E)-1-(4-hydroxy-3,5-dinitrophenyl)-3-(4-methylphenyl)propenone 
• 110798-89-5 N,N'-[2-hydroxy-5-(1-hydroxy-ethyl)-m-phenylene]-bis-benzamide 

Relevant academic research and scientific papers

PEG-N2O4: An efficient nitrating agent for the selective mono- and dinitration of phenols under mild conditions

N2O4 was easily impregnated on polyethyleneglycol to give a stable reagent. The polyethyleneglycol-N2O4 (PEG-N2O4) system was used as an effective nitrating agent for the nitration of phenols. Mono- and dinitrophenols can be obtained via direct nitration of phenols in the presence of PEG-N2O4 at room temperature in moderate to high yields. Copyright Taylor & Francis Group, LLC.

Trichloroisocyanuric Acid/NaNO2/wet SiO2 as an Efficient System for the Selective Dinitration of Phenols under Solvent-free Conditions

Dinitrophenols can be obtained via direct nitration of phenols with trichloroisocyanuric acid, NaNO2 and wet SiO2 at room temperature under solvent-free conditions with moderate to high yields.

Silica-acetate complex of N2O4: A heterogeneous reagent for the selective nitration of phenols and nitrosation of thiols

Complexation of gaseous N2O4 with acylated silica gel affords an addition compound, which is an efficient heterogeneous reagent for the selective mono- and dinitration of phenol, substituted phenols and nitrosation of thiols.

Silica-polyethyleneglycols/N2O4 complexes as heterogeneous nitrating and nitrosating agents

Silica-chloride was reacted with different quantities of H(OCH2CH2)nOH (n = 2-4) to furnish silica-based linear polyethylene glycols and cyclic polyethylene glycolic ethers. The N2O4 complex of silica-tetraethylene glycolic ether (III) was selected and used as a stable, cheap, and heterogeneous silica-based reagent for the selective mono- and dinitration of phenols and nitrosation of thiols.

Substituted alkylaryl ketones and methods of use as herbicides

Ring and side chain substituted alkylaryl ketones are useful in controlling the growth of germinating and seedling weed grasses and germinating and seedling broadleaf weeds.