521295-49-8

Basic information

• Product Name: 2-(4-(tert-butyl)phenyl)-1H-indole
• Synonyms: 2-(4-(tert-butyl)phenyl)-1H-indole
• CAS NO: 521295-49-8
• Molecular Weight: 249.356
• Mol File: 521295-49-8.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 2-(4-(tert-butyl)phenyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(tert-butyl)phenyl)-1H-indole(521295-49-8)
• EPA Substance Registry System: 2-(4-(tert-butyl)phenyl)-1H-indole(521295-49-8)

Safety Data

• Hazardous Substances Data: 521295-49-8(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 35779-04-5 1-tert-butyl-4-iodobenzene 
• 88576-64-1 4-tert.-Butyl-benzolsulfinsaeure 
• 15084-51-2 4-tert-butylbenzenesulfonyl chloride 
• 609-73-4 o-nitroiodobenzene 
• 772-38-3 4-tert-Butylphenylacetylene 
• 1321627-87-5 1-tert-butyl-4-(2-(2-nitrophenyl) ethynyl) benzene 
• 615-36-1 2-bromoaniline 
• 615-37-2 ortho-methylphenyl iodide 
• 4210-32-6 4-tert-butyl benzonitrile 
• 88-72-2 1-methyl-2-nitrobenzene 
• 943-27-1 4'-t-butylacetophenone 
• 95-52-3 2-Fluorotoluene 
• 123324-71-0 p-tert-butylphenylboronic acid 

Downstream Products

• 1360599-23-0 2-(4-(tert-butyl)phenyl)-1-methyl-1H-indole 

Relevant articles and documents

Acid-catalyzed cleavage of C-C bonds enables atropaldehyde acetals as masked C2 electrophiles for organic synthesis

Acid-catalyzed tandem reactions of atropaldehyde acetals were established for the synthesis of three important molecules, 2,2-disubstituted indolin-3-ones, naphthofurans and stilbenes. The synthesis was realized using novel reaction cascades, which involved the same two initial steps: (i) SN2′ substitution, in which the atropaldehyde acted as an electrophile; and (ii) oxidative cleavage of the carbon-carbon bond of the generated phenylacetaldehyde-type products. Compared with literature methods, the present protocol not only avoided the use of expensive noble metal catalysts, but also enabled a simple operation.

Iminyl-radicals by electrochemical decarboxylation of α-imino-oxy acids: construction of indole-fused polycyclics

Iminyl radicals are reactive intermediates that can be used for the construction of various valuable heterocycles. Herein, the electrochemical decarboxylation of α-imino-oxy acids for the generation of iminyl radicals has been accomplished under exogenous-oxidant- and metal-free conditions through the use ofnBu4NBr as a mediator. The resulting iminyl radicals undergo intramolecular cyclization smoothly with the adjacent (hetero)arenes to afford a series of indole-fused polycyclic compounds.

Pd-catalyzed C–H bond activation of Indoles for Suzuki reaction

Abstract: We present a practical method for Suzuki coupling by which unprotected or N-protected indoles may be selectively arylated in the C2-position through direct C–H bond activation by electrophilic Pd(TFA) 2 catalyst. The protocol is operationally simple as it is carried out in dioxane/water mixture, and air as the sole oxidant at room temperature. Various 2-arylated indoles were obtained in good yields. The protocol works for benzofuran, pyrrole and thiophene also. Graphic abstract: Selective C-2 arylation of heterocycles using Pd(II) catalyst via C–H activation was performed under ambient condition. C3–C2 migration of organopalladium intermediate controls the reaction pathway.[Figure not available: see fulltext.].