5215-07-6Relevant academic research and scientific papers
Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
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Page/Page column 67, (2008/12/06)
Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.
Methods for the construction of new highly functionalised guanidines
Wellner, Eric,Sandin, Helena,Swanstein, Marie-Louise
, p. 1817 - 1819 (2007/10/03)
In this study, we present a fast and chemoselective protocol to highly functionalised guanidines. Guanidines containing a hydroxy function were constructed in the microwave by regioselective ring opening of epoxides in the presence of ammonium hydroxide giving the primary amines, which then were reacted with isothiouronium salts. Direct coupling of an unsubstituted guanidine with an epoxide in the presence of n-BuLi gave the same product.
Bicyclic oxazole and thiazole substituted ethers
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, (2008/06/13)
The invention concerns oxazole and thiazole compounds of formula where the substituents have various significances, in free form or salt form as appropriate. They can be prepared e.g. by coupling or hydrolysis. The compounds can be used as pharmaceuticals, especially as hypoglycemic agents in the treatment of diabetes.
