52176-33-7Relevant academic research and scientific papers
TOLL-LIKE RECEPTOR 8 AGONISTS
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, (2015/07/07)
Compounds described herein can be used for therapeutic purposes. The compounds can be TLR agonists, such as TLR8 agonists. The compounds can be included in pharmaceutical compositions and used for therapies were being a TLR8 agonist is useful. The pharmac
Structure-based design of novel human toll-like receptor 8 agonists
Kokatla, Hari Prasad,Sil, Diptesh,Tanji, Hiromi,Ohto, Umeharu,Malladi, Subbalakshmi S.,Fox, Lauren M.,Shimizu, Toshiyoki,David, Sunil A.
, p. 719 - 723 (2014/05/06)
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds might be promising candidate vaccine adjuvants. Recently, a C2-butyl furo[2,3-c]
Antimicrobial 2 amino 4 alkoxyquinolines: synthesis and analysis of structure activity correlations
Actor,Berkoff,Craig,Julius,Redl,Grout,Hynam,Partridge
, p. 8 - 11 (2007/10/04)
The synthesis and in vitro antimicrobial activity of 28 2 amino 4 alkoxyquinolines against 4 species of Gram positive and 4 species of Gram negative bacteria and 4 species of fungi are reported. For the analysis of structure activity correlations the Free Wilson (FW) approach was explored but the nature of the data did not meet the requirements considered mandatory for a meaningful application of the FW method. Composite activities against the 3 different classes of microorganisms indicate that optimal activity rests primarily on the nature of the alkyl group at the 4 alkoxy position, where increasing chain length leads to increasing activity against Gram positive bacteria and fungi. The level of activity against Gram negative bacteria is too low for meaningful trends to be observed. Alkylation or acylation of the 2 amino group and substitution at the 3 position are detrimental to activity against all 3 classes of organisms.
