52179-07-4Relevant academic research and scientific papers
Microwave-assisted synthesis, hypolipidemic and hypoglycemic activity of some novel 2-(4-(2-amino-6-(4-substituted phenyl)-pyrimidin-4-yl)-phenoxy)-2- methyl propanoic acid derivatives
Mokale, Santosh N.,Elgire, Rupali D.,Sakle, Nikhil S.,Shinde, Devanand B.
experimental part, p. 22 - 27 (2012/03/10)
A novel series of aminopyrimidines containing the phenoxy isobutyric acid group as a pharmacophore was synthesized using conventional and microwave assisted methods of synthesis. The compounds were synthesized in good yields (70-89%) by the microwave-assisted one-pot protocol in much shorter reaction times. The synthesized compounds were evaluated for their hypolipidemic and hypoglycemic activity by high-fat diet-induced hyperlipidemia and hyperglycemia in male Sprague-Dawley rats. The present investigation showed significant antihyperlipidemic and antihyperglycemic activity for all compounds of the series when compared with the standard drug. Structure-activity relationship (SAR) for the series were developed by comparing total lipid profile data of synthesized compounds with fenofibrate as standard drug. A novel series of aminopyrimidines containing the phenoxy isobutyric acid group as a pharmacophore was synthesized using conventional and microwave-assisted methods of synthesis. The synthesized compounds were evaluated for their hypolipidemic and hypoglycemic activities on high-fat diet-induced hyperlipidemia and hyperglycemia in male Sprague-Dawley rats. Copyright
Synthesis, hypolipidemic and hypoglycemic activity of some novel 2-(4-(2-substituted aminothiazole-4-yl) phenoxy)-2-methyl propanoic acid derivatives
Mokale, Santosh N.,Elgire,Sakle, Nikhil,Shinde, Devanand B.
experimental part, p. 682 - 685 (2011/03/18)
An improved synthetic protocol for a novel series of 2-(4-(2-substituted aminothiazole-4-yl) phenoxy)-2-methyl propanoic acid derivatives has been developed using different methods of synthesis. The synthesized compounds are evaluated for their hypolipidemic and hypoglycemic activity by high fat diet induced hyperlipidemia and hyperglycemia in Sprague-Dawley rats.
Degradation Studies under Neutral and Basic Conditions on Ciprofibrate, an Orally Active Hypolipidemic Agent Containing a (4-Alkoxyaryl)-1,1-dichlorocyclopropane Unit
Dulayymi, Juma'a R. Al,Baird, Mark S.,Byard, Stephen J.,Carr, Glynis,Ellames, George J.,et al.
, p. 43 - 48 (2007/10/02)
The major product of degradation of ciprofibrate (1), 2-(4-(2,2-dichlorocyclopropyl)phenoxy>-2-methylpropanoic acid, in aqueous sodium hydroxide under reflux is 2--2-methylpropanoic acid (11).A further product, 2-(4-ethynylphenoxy)-2-methylpropanoic acid (12) is derived from 11 under the reaction conditions.A third degradant is identified as 2--2-methylpropanoic acid (13).Under similar conditions, but at pH 7, the products of degradation were found to be2--2-methylpropanoic acid (9) and (Z)-2--2-methylpropanoic acid (10).Treatment of 10 with aqueous sodium hydroxide under reflux afforded a mixture of products in which 11 and 12 predominated, whereas similar treatment of 9 led to compound 13 among other products.A labelling study indicates that the acid 21 derived from base treatment of 17 is labelled only at C-2 of the propanoic acid side chain; the same labelling pattern is observed in the acid 21 derived by base treatment of the labelled allylic alcohol 18.Mechanisms are suggested which may explain these observations.
Halocyclopropyl substituted phenoxyalkanoic acids
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, (2008/06/13)
Halocyclopropyl substituted phenoxyalkanoic acids and esters thereof, having hypocholesteremic activity are prepared via several alternative synthetic approaches, involving as the key reactions interaction of a substituted phenylalkene with a carbene source to introduce the halocyclopropyl moiety, and reaction of a substituted phenol with chloroform and a lower-alkanone in the presence of base, or with a lower-alkyl α-bromo-alkanoate, to form the phenoxyalkanoic acid moiety.
