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(17beta)-17-hydroxyestra-5(10),9(11)-dien-3-one, also known as 17β-hydroxyestradiol, is a synthetic form of the natural female hormone estrogen. It is a derivative of estradiol, the primary female sex hormone, and is characterized by its ability to mimic the effects of estrogen in the body.
Used in Hormone Replacement Therapy:
(17beta)-17-hydroxyestra-5(10),9(11)-dien-3-one is used as a hormone supplement for treating symptoms of menopause, such as hot flashes and vaginal dryness. It helps to alleviate these symptoms by supplementing the body's natural estrogen levels, which decrease during menopause.
Used in Birth Control Pills:
(17beta)-17-hydroxyestra-5(10),9(11)-dien-3-one is used as a component in some birth control pills to prevent pregnancy. It works by suppressing ovulation and altering the cervical mucus to prevent sperm from reaching the egg.
Used in Cancer Treatment:
(17beta)-17-hydroxyestra-5(10),9(11)-dien-3-one is used as a treatment for certain forms of breast cancer. It can help to slow or stop the growth of cancer cells by interfering with the hormone's effects on the cells.
It is important for individuals to consult with a healthcare professional before using (17beta)-17-hydroxyestra-5(10),9(11)-dien-3-one, as it may have potential side effects and interactions with other medications.

5218-51-9

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5218-51-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5218-51-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,1 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5218-51:
(6*5)+(5*2)+(4*1)+(3*8)+(2*5)+(1*1)=79
79 % 10 = 9
So 5218-51-9 is a valid CAS Registry Number.

5218-51-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 17-β-Hydroxyoestra-5(10),9(11)-dien-3-on

1.2 Other means of identification

Product number -
Other names (S)-17-Hydroxy-13-methyl-1,2,4,6,7,8,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5218-51-9 SDS

5218-51-9Downstream Products

5218-51-9Relevant academic research and scientific papers

Method for preparing pufferone acetate (by machine translation)

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Paragraph 0047-0054, (2019/11/21)

The invention discloses a method for preparing pufferone acetate, and belongs to the technical field of preparation and processing of hormone drugs. The process is carried out 3 - with ethylenedioxy estra-Δ. 5,10 , Δ9,11 -17-ketone is a starting raw material, and the preparation of the 3 botanerone acetate is carried out by 17 reducing the position of the ketone as an alcohol, hydrolyzing the position of the furanone, the 17 oxidative dehydrogenation, and the alcohol acetylation. The method has the advantages of cheap and easily available raw materials, simple reaction control, few byproducts, easy purification and high total yield, has extremely high competitiveness in production cost and operability, is suitable for industrial large-scale production and has good economic benefits. (by machine translation)

Synthesis method of trenbolone acetate

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Paragraph 0008; 0025; 0028; 0029, (2018/05/30)

The invention provides a synthesis method of trenbolone acetate. The synthesis method comprises the following steps: step 1), dissolving a 4,9 ring-opening object (I) into methanol; adding potassium borohydride fractionally at 20 to 25 DEG C; after adding the potassium borohydride, carrying out heat preservation and reacting until a TLC (Thin-Layer Chromatography) analysis raw material is completely reacted, so as to obtain a compound (II); step 2), adding diluted acid into a reaction system for finishing reaction of step 1) and regulating the pH (Potential of Hydrogen) value to be neutral; dropwise adding dilute sulfuric acid and carrying out water separation to obtain 17beta-hydroxy-estra-5(10),9(11)-diene-3-one (III); step 3) dissolving the compound (III) into dichloromethane and addingDDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone) and completely reacting; filtering; washing filtrate and combining a water layer; extracting the water layer by the dichloromethane; combining all dichloromethane layers; dehydrating, vacuum concentrating and drying to obtain trenbolone (IV); step 4) dissolving the trenbolone (IV) into the dichloromethane; adding DMAP (4-dimethylamiopryidine) and acetic anhydride and completely reacting to obtain the trenbolone acetate.

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