52182-32-8Relevant academic research and scientific papers
One-pot synthesis of multifunctionalized cyclopropanes
Chang, Meng-Yang,Chen, Yi-Chia,Chan, Chieh-Kai
, p. 2257 - 2263 (2014)
A facile one-step synthetic protocol toward multifunctionalized cyclopropanes 4 is developed from substituted chalcones 1 and sulfones 2 in good yields via a [2C+1C] annulation.
Lewis acid catalyst system for Claisen-Schmidt reaction under solvent free condition
Halpani, Chandni G.,Mishra, Satyendra
, (2020/07/16)
Ca(OTf)2 in combination with NBu4.BF4 was established to function as an efficient catalyst system for one-pot Claisen-Schmidt condensation under neat conditions. Substituted acetophenones and benzaldehydes were coupled in situ to afford their corresponding chalcones in excellent yields. The method, with a broad range of substrate tolerance and mild operational conditions can produce assorted chalcone derivatives in moderate to high yields from easily accessible starting materials.
Synthesis of 3-aroylimidazo[1,2-a]pyridines via CuCl2 catalyzed tandem dual carbon-nitrogen bonding
Kaswan, Pinku,Pericherla, Kasiviswanadharaju,Rajnikant,Kumar, Anil
, p. 8539 - 8544 (2014/12/10)
A novel tandem approach has been demonstrated for the direct synthesis of bioactive 3-aroylimidazo[1,2-a]pyridines from chalcones and 2-aminopyridines. The reported tandem reaction is atom-economical and expected to proceed via 1,4-Michael addition follow
One-pot synthesis of multifunctionalized m-terphenyls
Chang, Meng-Yang,Chan, Chieh-Kai,Lin, Shin-Ying,Wu, Ming-Hao
, p. 9616 - 9624 (2013/10/22)
A facile one-step synthetic protocol toward multifunctionalized m-terphenyls 5 and sulfonyl m-terphenyls 6 is developed from substituted chalcones 1 and allyl sulfone 2 in good yields via a [3C+3C] annulation. The NaH-mediated annulation features transition metal catalyst-free condition. Chalcones 1 with the functional groups tolerance are easily prepared via Claisen-Schmidt condensation of substituted benzaldehydes 3 with acetophenone 4 in a qualitative yield under an aqueous alkaline methanolic solution.
Interactive free energy relationships for non-additive multiple substituent effects in base catalysed condensation of benzaldehydes with acetophenones: A kinetic study
Sondu, S.,Sethuram, B,Rao, T. Navaneeth
, p. 67 - 69 (2007/10/02)
The base-catalysed condensation of benzaldehydes with acetophenones is enhanced by electron-withdrawing substituents in both starting compounds.The magnitude of ρ-value obtained for various substituents in the benzaldehyde moiety decreases with the introduction of electron-withdrawing groups in the para position of acetophenone moiety.
