52187-00-5Relevant academic research and scientific papers
Efficient preparation of medium ring oxygen heterocycles
Nishiguchi, Atsuko,Ikemoto, Tomomi,Ito, Tatsuya,Miura, Shotaro,Tomimatsu, Kiminori
, p. 445 - 452 (2008/02/09)
We achieved efficient preparation of medium ring oxygen heterocycles (1), 1-benzoxepines and 1-benzoxocines, by applying intramolecular Claisen-type condensation in dialkyl carbonate with metal alcoholate. Furthermore, we accomplished the preparation of 2
Synthesis of Aryloxy Analogues of Arachidonic Acid via Wittig and Palladium Catalysed Cross-coupling Reactions
Buckle, Derek R.,Fenwick, Ashley E.,Outred, D. James,Rockell, Caroline J. M.
, p. 3144 - 3177 (2007/10/02)
The synthesis of o- and p-phenoxy analogues of arachidonic acid is described.In particular, the Wittig olefination reaction of hydroxy and alkyloxy benzaldehydes has been investigated and the products shown to be highly dependent on the solvent used.E/Z isomer control was difficult to achieve in most cases, although there was a tendency towards Z-isomer formation in dimethyl sulphoxide compared to tetrahydrofuran, particularly for the phenolic compounds.Specific Z-isomer formation was achieved by the partial reduction of alkynes derived from appropriately protected bromophenols via Heck or palladium catalysed cross-coupling reactions.
