521916-72-3Relevant academic research and scientific papers
A concise synthesis of (-)-codonopsinine and an approach to synthesis of (+)-hyacinthacines A1 and A2 from a polyhydroxylated cyclic nitrone
Toyao, Atsushi,Tamura, Osamu,Takagi, Hiroko,Ishibashi, Hiroyuki
, p. 35 - 38 (2007/10/03)
Synthesis of (-)-codonopsinine (2) was accomplished in seven steps that involved an addition of five-membered cyclic nitrone 1, readily obtained from L-xylose, with the Grignard reagent. Nitrone 1 also underwent intermolecular cycloaddition with several α,β-unsaturated esters 12 to afford cycloadducts 13, one of which, 13c, was elaborated to the key intermediate 17 for (+)-hyacinthacines A1 (3a) and A2 (3b).
