52201-34-0Relevant academic research and scientific papers
Influence of bases and ligands on the outcome of the Cu(I)-catalyzed oxidative homocoupling of terminal alkynes to 1,4-disubstituted 1,3-diynes using oxygen as an oxidant
Adimurthy, Subbarayappa,Malakar, Chandi C.,Beifuss, Uwe
experimental part, p. 5648 - 5651 (2009/12/08)
(Chemical Equation Presented) The efficient Cu(I)-catalyzed oxidative homocoupling of terminal alkynes in the presence of a base using an amine as a ligand and oxygen as an oxidant yields the symmetrical 1,3-diynes with yields of up to 99%. The outcome of the couplings critically depends on the proper choice of base and ligand as well as reaction conditions. Best results were observed with 2.0 mol%CuCl, 1.5 mol%TMEDA or DBEDA, and DBU or DABCO in acetonitrile.
