52210-86-3

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Imidazolidinone, 1-(4-piperidinyl)is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides with improved efficacy and safety.
Used in Asymmetric Synthesis:
2-Imidazolidinone, 1-(4-piperidinyl)serves as a chiral auxiliary in asymmetric synthesis, enabling the production of enantiomerically pure compounds, which are crucial for the pharmaceutical industry to ensure the desired biological activity and minimize side effects.
Used in Organic Reactions:
As a catalyst, 2-Imidazolidinone, 1-(4-piperidinyl)facilitates various organic reactions, enhancing the efficiency and selectivity of chemical processes, which is essential for the synthesis of complex molecules and the development of advanced materials.
Used in Anti-Inflammatory and Analgesic Applications:
2-Imidazolidinone, 1-(4-piperidinyl)has been studied for its potential as an anti-inflammatory and analgesic agent, offering a new avenue for the treatment of pain and inflammation, which are common symptoms in various medical conditions.
Used in Corrosion Inhibition:
2-Imidazolidinone, 1-(4-piperidinyl)acts as a corrosion inhibitor, protecting metal surfaces from degradation and extending the lifespan of materials used in various industries, such as automotive, aerospace, and construction.
Used in Polymers and Coatings Industry:
As an additive in polymers and coatings, 2-Imidazolidinone, 1-(4-piperidinyl)enhances the properties of these materials, improving their performance, durability, and resistance to environmental factors, thus contributing to the development of innovative products in the coatings and polymers market.

Upstream product

• 72349-01-0 benzyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate 

Downstream Products

• 72349-01-0 benzyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate 
• 72822-54-9 1-[1-[2-(1,4-benzodioxan-2-yl)-ethyl]-4-piperidyl]-2-imidazolidinone 
• 783248-07-7 1-{1-[4-(4-fluoro-phenyl)-4-oxo-butyl]-piperidin-4-yl}-imidazolidin-2-one 
• 61220-45-9 1-[3-(3-chlorophenyl)-propyl]-4-(1,3-ethyleneureido)-piperidine 

Relevant academic research and scientific papers

Discovery of a tetrahydropyrimidin-2(1 H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor

Coagulation enzyme factor Xa (FXa) is a particularly promising target for the development of new anticoagulant agents. We previously reported the imidazo[1,5-c]imidazol-3-one derivative 1 as a potent and orally active FXa inhibitor. However, it was found that 1 predominantly undergoes hydrolysis upon incubation with human liver microsomes, and the human specific metabolic pathway made it difficult to predict the human pharmacokinetics. To address this issue, our synthetic efforts were focused on modification of the imidazo[1,5-c] imidazol-3-one moiety of the active metabolite 3a, derived from 1, which resulted in the discovery of the tetrahydropyrimidin-2(1H)-one derivative 5k as a highly potent and selective FXa inhibitor. Compound 5k showed no detectable amide bond cleavage in human liver microsomes, exhibited a good pharmacokinetic profile in monkeys, and had a potent antithrombotic efficacy in a rabbit model without prolongation of bleeding time. Compound 5k is currently under clinical development with the code name TAK-442.

PIPERIDINYL CYCLIC AMIDO ANTIVIRAL AGENTS

Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

Chemical compounds

Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

N-Oxacyclic-alkylpiperidines as psychostimulants

N-Oxacyclic-alkylpiperidyl-diazacompounds, e.g., those of the formula STR1 and salts thereof are antidepressants and psychostimulants.