Chondroitinase B, derived from Flavobacterium heparinum, is an enzyme that specifically cleaves chondroitin sulfate, a glycosaminoglycan found in the extracellular matrix of connective tissues. It plays a crucial role in the structural characterization and antithrombin activity of dermatan sulfate, as well as in the investigation of chondroitin lyase action patterns.
52227-83-5
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Basic information
- Product Name: CHONDROITINASE B
- Synonyms: CHONDROITINASE B;CHONDROITIN SULFATE B LYASE;EC 4.2.2.5;CHONDROITINASE B FROM FLAVOBACTERIUMHEPA RINUM LYOP;chondroitinase b from flavobacterium heparinum
- CAS NO:52227-83-5
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: CHONDROITINASE B(CAS DataBase Reference)
- NIST Chemistry Reference: CHONDROITINASE B(52227-83-5)
- EPA Substance Registry System: CHONDROITINASE B(52227-83-5)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 52227-83-5(Hazardous Substances Data)
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52227-83-5 Usage
Uses
Used in Pharmaceutical Industry:Chondroitinase B is used as a research tool for studying the structural characterization and antithrombin activity of dermatan sulfate. It aids in understanding the interactions between dermatan sulfate and antithrombin, which is essential for the development of therapeutic strategies targeting blood clotting and related disorders.
Used in Biotechnology Industry:
Chondroitinase B is employed as an analytical tool in the investigation of chondroitin lyase action patterns via liquid chromatography–mass spectrometry. This application helps researchers gain insights into the enzymatic processes involved in the degradation of chondroitin sulfate, which can be valuable for the development of novel biotechnological applications and therapies.
Biochem/physiol Actions
Chondroitinase B degrades only chondroitin sulphate B producing oligo- and tetra-saccharides, and an unsaturated 4-sulphated disaccharide. It has an optimum temperature of 20 °C and an optimum pH of 8.0. The enzyme activity is inhibited by 50% using 0.1 M NaCI. Co2+, Fe3+ and Ba2+ also inhibit its activity.Check Digit Verification of cas no
The CAS Registry Mumber 52227-83-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,2,2 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.Calculate Digit Verification of CAS Registry Number 52227-83:
(7*5)+(6*2)+(5*2)+(4*2)+(3*7)+(2*8)+(1*3)=105
105 % 10 = 5
So 52227-83-5 is a valid CAS Registry Number.
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CHONDROITINASE B
