52238-39-8

Downstream Products

• 1449792-86-2 N-benzyl-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide 
• 1449792-88-4 N-(2-chlorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide 
• 1449792-90-8 N-(4-fluorobenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide 
• 1449792-92-0 N-(4-methylbenzyl)-4-hydroxy-2-(N-methyl-4,4-diphenylbutylamino)butanamide 
• 1449792-34-0 3-[(4,4-diphenylbutyl)(methyl)amino]dihydrofuran-2(3H)-one 
• 1621342-19-5 4-(1,3-dioxoisoindolin-2-yl)-2-((4,4-diphenylbutyl)(methyl)amino)-N-(4-methylbenzyl)butanamide 
• 1621342-17-3 4-(1,3-dioxoisoindolin-2-yl)-2-((4,4-diphenylbutyl)(methyl)amino)-N-(4-fluorobenzyl)butanamide 
• 1621342-15-1 N-(4-chlorobenzyl)-4-(1,3-dioxoisoindolin-2-yl)-2-((4,4-diphenylbutyl)(methyl)amino)butanamide 
• 1621342-13-9 N-(2-chlorobenzyl)-4-(1,3-dioxoisoindolin-2-yl)-2-((4,4-diphenylbutyl)(methyl)amino)butanamide 
• 1621342-12-8 N-benzyl-4-(1,3-dioxoisoindolin-2-yl)-2-((4,4-diphenylbutyl)(methyl)amino)butanamide 

Relevant academic research and scientific papers

2-Substituted 4-hydroxybutanamides as potential inhibitors of γ-aminobutyric acid transporters mGAT1-mGAT4: Synthesis and biological evaluation

A series of 2-substituted 4-hydroxybutanamide derivatives has been synthesized by the aminolysis of appropriate 2-substituted dihydrofuran-2(3H)- one derivatives with various substituted benzylamines. The final compounds have been evaluated for their capability of inhibiting the GABA transport proteins GAT1-4 stably expressed in HEK-239 cell lines. The pIC50 values determined were in the range 4.21-5.14. Two compounds (16a and 16d), which displayed the most interesting profiles in in vitro tests, have also been subjected to further preliminary behavioral studies, evaluating their antinociceptive activity in hot-plate, writhing, and formalin tests. Their influence on motor coordination has also been assessed.