52240-00-3

Basic information

• Product Name: 4,5-Dihydro-6-(2-thienyl)-3(2H)-pyridazinone
• Synonyms: 4,5-Dihydro-6-(2-thienyl)-3(2H)-pyridazinone;6-(Thiophen-2-yl)-4,5-dihydropyridazin-3(2H)-one
• CAS NO: 52240-00-3
• Molecular Formula: C₈H₈N₂OS
• Molecular Weight: 180.22692
• Mol File: 52240-00-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,5-Dihydro-6-(2-thienyl)-3(2H)-pyridazinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dihydro-6-(2-thienyl)-3(2H)-pyridazinone(52240-00-3)
• EPA Substance Registry System: 4,5-Dihydro-6-(2-thienyl)-3(2H)-pyridazinone(52240-00-3)

Safety Data

• Hazardous Substances Data: 52240-00-3(Hazardous Substances Data)

Upstream product

• 4653-08-1 4-oxo-4-thiophen-2-yl-butyric acid 
• 87702-21-4 4-(thien-2-yl)-4-oxobutyric acid methyl ester 

Downstream Products

• 123716-48-3 4-(4-methoxybenzyl)-6-(thiophen-2-yl)pyridazin-3(2H)-one 
• 1444311-20-9 4-(3-methoxybenzyl)-6-(thiophen-2-yl)pyridazin-3(2H)-one 
• 1444311-48-1 2-[5-(3-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid 
• 1444311-47-0 2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetic acid 
• 1444311-32-3 ethyl 2-[5-(3-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetate 
• 1444311-31-2 ethyl 2-[5-(4-methoxybenzyl)-6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl]acetate 
• 78490-15-0 (bromo-5 thienyl-2)-6 tetrazolo<1,5-b>pyridazine 
• 54558-07-5 6-(thien-2-yl)-2,3-dihydropyridazin-3-one 
• 28657-41-2 3-chloro-6-(2'-thienyl)pyridazine 
• 75792-87-9 3-hydrazino-6-thien-2-ylpyridazine 

Relevant articles and documents

Synthesis, anti-convulsant activity and molecular docking study of novel thiazole pyridazinone hybrid analogues

Pyridazinone analogues have been known to be potential candidates for anticonvulsant agents. We have identified several pyridazinone-based anticonvulsant agents. As a continuation to our previous research, a series of hybrid pyridazinone-thiazole connected through amide linkage were designed and synthesized. Among these, compound SP-5F demonstrated significant anticonvulsant activity with median effective dose of 24.38 mg/kg (MES) and 88.23 mg/kg (scPTz). Results of GABA estimation showed a marked increase in the GABA level when compared with control. Molecular docking studies at the active site of GABA receptor, further confirmed the GABA modulatory effects of SP-5F.

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: Design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists

Formyl peptide receptors (FPRs) play an essential role in the regulation of endogenous inflammation and immunity. In the present studies, a large series of pyridazin-3(2H)-one derivatives bearing an arylacetamide chain at position 2 was synthesized and te

Endothelin receptor antagonists

This invention relates to pyridizinone derivatives of formula I STR1 wherein the various substituents are defined in the specification, and salts thereof, which have useful pharmacological properties, in particular endothelin receptor-antagonistic properties. The compounds are thus useful for the treatment of illnesses associated with endothelin activities, such as hypertension, cardiac insufficiency, coronary heart disease, renal, cerebral and myocardial ischaemia, renal insufficiency, cerebral infarct, subarachnoid haemorrhage, arteriosclerosis pulmonary high blood pressure, inflammations, asthma, prostate hyperplasia, endotoxic shock and in complications after the administration of immunosuppressants which produce renal vasoconstriction.