52247-77-5

Usage

Uses

Used in Pharmaceutical Research and Chemical Manufacturing:
(S)-(+)-2-Amino-2-phenylbutyric acid is used as a chiral building block for the synthesis of pharmaceuticals and other organic compounds. Its unique chiral center allows for the creation of enantiomerically pure products, which is crucial for the development of effective and safe medications.
Used in Biochemical Studies:
L-Phenylglycine is utilized in biochemical research to investigate the properties and functions of chiral molecules. Its presence in various biological systems and its ability to interact with other chiral compounds make it an important tool for understanding the role of chirality in biological processes.
Used in Medical Diagnostic Testing:
(S)-(+)-2-Amino-2-phenylbutyric acid is employed in the development of diagnostic tests that rely on the detection and analysis of chiral compounds. Its distinctive properties enable the accurate identification and quantification of target molecules, contributing to the advancement of medical diagnostics.
Used in the Production of Chiral Ligands and Catalysts:
L-Phenylglycine is used as a key component in the synthesis of chiral ligands and catalysts, which are essential for enantioselective reactions in organic chemistry. These chiral catalysts and ligands facilitate the production of enantiomerically pure compounds, which are vital for various applications, including pharmaceuticals, agrochemicals, and fragrances.

InChI:InChI=1/C10H13NO2/c1-2-10(11,9(12)13)8-6-4-3-5-7-8/h3-7H,2,11H2,1H3,(H,12,13)/t10-/m0/s1

Upstream product

• 220599-84-8 (S)-2-formylamino-2-phenyl-butyric acid 
• 144095-19-2 rac-α-ethyl-phenylglycine 
• 205654-79-1 (2S,4S)-3-benzyloxycarbonyl-2,4-diphenyl-1,3-oxazolidin-5-one 
• 220599-90-6 (+/-)-2-formylamino-2-phenyl-butyric acid 
• 5438-07-3 2-amino-2-phenylbutanoic acid 

Downstream Products

• 52165-63-6 ethyl (S)-2-amino-2-phenylbutanoate 
• 84471-51-2 (S)-2-ureido-2-phenyl-butyric acid 
• 65567-34-2 (+)-Nirvanol 

Relevant academic research and scientific papers

Evaluation of the Edman degradation product of vancomycin bonded to core-shell particles as a new HPLC chiral stationary phase

A modified macrocyclic glycopeptide-based chiral stationary phase (CSP), prepared via Edman degradation of vancomycin, was evaluated as a chiral selector for the first time. Its applicability was compared with other macrocyclic glycopeptide-based CSPs: TeicoShell and VancoShell. In addition, another modified macrocyclic glycopeptide-based CSP, NicoShell, was further examined. Initial evaluation was focused on the complementary behavior with these glycopeptides. A screening procedure was used based on previous work for the enantiomeric separation of 50 chiral compounds including amino acids, pesticides, stimulants, and a variety of pharmaceuticals. Fast and efficient chiral separations resulted by using superficially porous (core-shell) particle supports. Overall, the vancomycin Edman degradation product (EDP) resembled TeicoShell with high enantioselectivity for acidic compounds in the polar ionic mode. The simultaneous enantiomeric separation of 5 racemic profens using liquid chromatography-mass spectrometry with EDP was performed in approximately 3?minutes. Other highlights include simultaneous liquid chromatography separations of rac-amphetamine and rac-methamphetamine with VancoShell, rac-pseudoephedrine and rac-ephedrine with NicoShell, and rac-dichlorprop and rac-haloxyfop with TeicoShell.

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.

Efficient biocatalytic synthesis of highly enantiopure α-alkylated arylglycines and amides

A number of racemic α-alkylarylglycine amides including 1-amino-1-carbamoyl-1,2,3,4-tetrahydronaphthalene underwent efficient biocatalytic hydrolysis under very mild conditions to afford the corresponding (S)-α-alkylarylglycines and (R)-α-alkylarylglycine

New methodology for the synthesis of α,α-dialkylamino acids using the "self-regeneration of stereocenters" Method: α-ethyl-α-phenylglycine

The stereoselective room temperature ethylations of protected oxazolidinones from phenylglycine by phase-transfer catalysis or with KOtBu as base are used to prepare optically active α-ethyl-α-phenylglycine.