522646-43-1

Usage

Uses

Used in Pharmaceutical Industry:
5-(2-fluoro-phenyl)-2-Methyl-thiazole-4-carboxylic acid is used as a reactant for the preparation of oxo-heterocyclic compounds, which are known as orexin receptor antagonists. These antagonists play a crucial role in the development of medications targeting various central nervous system disorders, such as insomnia, addiction, and other sleep-wake cycle-related conditions. 5-(2-fluoro-phenyl)-2-Methyl-thiazole-4-carboxylic acid's unique structure allows it to interact with orexin receptors, modulating their activity and providing therapeutic benefits.

Upstream product

• 1007875-07-1 methyl 5-(2-fluorophenyl)-2-methyl-1,3-thiazole-4-carboxylate 
• 1007875-06-0 methyl 3-chloro-3-(2-fluorophenyl)-2-oxopropanoate 
• 446-52-6 2-Fluorobenzaldehyde 

Relevant academic research and scientific papers

SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

There is provided a compound of formula (I), wherein L1 to L3, R1 to R4, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, which compounds are useful as antagonists of the orexin-1 and orexin-2 receptors or as selective antagonists of the orexin-1 receptor, and thus, in particular, in the treatment or prevention of inter alia substance dependence, addiction, anxiety disorders, panic disorders, binge eating, compulsive disorders, impulse control disorders, cognitive impairment and Alzheimer's disease.

1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to 3-aza-bicyclo[3.1.0]hexane derivatives of formula (I) wherein A, B, n, X, and R1 are as described in the description, and salts thereof, and their use as orexin receptor antagonists.

3-HETEROARYL (AMINO OR AMIDO)-1-(BIPHENYL OR PHENYLTHIAZOLYL) CARBONYLPIPERIDINE DERIVATIVES AS OREXIN RECEPTOR INHIBITORS

The invention relates to piperidine compounds of formula (I) wherein X-R1 represents —N(H)-pyrimidinyl, wherein said pyrimidinyl is unsubstituted or mono-substituted wherein the substituent is selected from (C1-4)alkyl or halogen, or

AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to novel azetidine compounds of formula (I), wherein R1, R2, and X are as described in the description and their use as orexin receptor antagonists.

TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

1,2-DIAMIDO-ETHYLENE DERIVATIVES

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) NHNR 3 OAOR 1 R 2 (I) wherein R1, R 2, R 3, and A are as described in the description and their use as medicaments, especially as orexin receptor

3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to 3-aza-bicyclo[3.1.0]hexane derivatives of formula (I) wherein A, B, n, X, and R1 are as described in the description, and salts thereof, and their use as orexin receptor antagonists.

PIPERIDINE COMPOUNDS

The invention relates to piperidine compounds of formula (I) wherein X-R1 represents -N(H)-pyrimidinyl, wherein said pyrimidinyl is unsubstituted or mono-substituted wherein the substituent is selected from (C1-4)alkyl or halogen, or