522665-65-2

Upstream product

• 522665-64-1 (3Z,5S,6S,7R,9S,11Z,13S,14R,15S)-6-[(aminocarbonyl)oxy]-14-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-16-[(4-methoxyphenyl)methoxy]-5,7,9,11,13,15-hexamethyl-1,3,11-hexadecatrien-8-one 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 132969-60-9 (2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal 
• 212703-47-4 2,4-dideoxy-3-O-[(1,1-dimethylethyl)dimethylsilyl]-5-O-[(4-methoxyphenyl)-methyl]-2,4-dimethyl-L-arabinose 
• 212703-48-5 (1,1-dimethylethyl)[[(1R,2S,3Z)-4-iodo-1-[(1S)-2-[(4-methoxyphenyl)methoxy]-1-methylethyl]-2-methyl-3-pentenyl]oxy]dimethylsilane 
• 522665-51-6 (2S,3Z)-2-methyl-3,5-hexadien-1-al 
• 522665-53-8 (2S,3Z)-2-methyl-3,5-hexadien-1-ol 
• 522665-52-7 1-methoxy-4-[[[(2S,3Z)-2-methyl-3,5-hexadienyl]oxy]methyl]benzene 
• 522665-54-9 (2S,3R,4S)-1-[(4-methoxyphenyl)methoxy]-2,4-dimethyl-5-hexen-3-ol 
• 522665-55-0 (1,1-dimethylethyl)[[(1R,2S)-1-[(1S)-2-[(4-methoxyphenyl)methoxy]-1-methylethyl]-2-methyl-3-butenyl]oxy]dimethylsilane 
• 522665-56-1 (2S,4Z,6S,7R,8S)-7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-9-[(4-methoxyphenyl)methoxy]-2,4,6,8-tetramethyl-4-nonenoic acid methyl ester 
• 522665-50-5 (4S,6Z,8S,9R,10S)-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-11-[(4-methoxyphenyl)methoxy]-4,6,8,10-tetramethyl-6-undecen-3-one 
• 522665-63-0 (3Z,5S,6S,7R,9S,11Z,13S,14R,15S)-14-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-hydroxy-16-[(4-methoxyphenyl)methoxy]-5,7,9,11,13,15-hexamethyl-1,3,11-hexadecatrien-8-one 
• 522665-57-2 (2S,4Z,6S,7R,8S)-7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-methoxy-9-[(4-methoxyphenyl)methoxy]-N,2,4,6,8-pentamethyl-4-nonenamide 

Downstream Products

• 522665-66-3 (3Z,5S,6S,7R,8R,9S,11Z,13S,14R,15S)-8,14-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-16-[(4-methoxyphenyl)methoxy]-5,7,9,11,13,15-hexamethyl-1,3,11-hexadecatrien-6-carbamate 

Relevant academic research and scientific papers

Formal synthesis of (+)-discodermolide.

[structure: see text] Herein we report the formal total synthesis of (+)-discodermolide in 21 steps (longest linear sequence) from commercially available Roche ester. This synthesis features the assembly of C(9-18) and C(19-24) fragments via a metal-chelated aldol coupling reaction.