5228-48-8

Basic information

• Product Name: 2-METHYL-5-NITRO-2H-INDAZOLE
• Synonyms: 2H-Benzopyrazole, 2-methyl-5-nitro-;2H-Indazole, 2-methyl-5-nitro-;2-METHYL-5-NITRO-2H-INDAZOLE;Methylnitroindazole;2-Methyl-5-nitro-2H-indazole, 98+%;2-methyl-5-nitroindazole;2-methyl-5-nitro-indazole;2-Methyl-5-nitro-1H-indazole
• CAS NO: 5228-48-8
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.16
• Product Categories: Indazoles
• Mol File: 5228-48-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 129-131°C
• Boiling Point: 364.5°Cat760mmHg
• Flash Point: 174.2°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 167044
• CAS DataBase Reference: 2-METHYL-5-NITRO-2H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-5-NITRO-2H-INDAZOLE(5228-48-8)
• EPA Substance Registry System: 2-METHYL-5-NITRO-2H-INDAZOLE(5228-48-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• HazardClass: IRRITANT
• Hazardous Substances Data: 5228-48-8(Hazardous Substances Data)

Usage

General Description

2-Methyl-5-nitro-2H-indazole is a chemical compound with the molecular formula C9H7N3O2. It is an organic compound that contains a nitro group and an indazole ring. It is a yellow solid with a melting point of 190-192°C and it is used in the synthesis of various pharmaceutical compounds. It is also known for its potential biological activity, including its role as an inhibitor of certain enzymes. This chemical compound is commonly used in medicinal chemistry and pharmaceutical research for the development of new drugs and therapeutic agents.

InChI:InChI=1/C8H7N3O2/c1-10-5-6-4-7(11(12)13)2-3-8(6)9-10/h2-5H,1H3

Upstream product

• 420-37-1 trimethoxonium tetrafluoroborate 
• 5401-94-5 5-nitroindazole 
• 99-52-5 2-methyl-4-nitro-benzenamine 
• 74-88-4 methyl iodide 
• 65750-01-8 5-nitro-2H-indazole 
• 2533-69-9 methyl 2,2,2-trichloroacetimidate 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 60518-59-4 5-amino-2-methyl-2H-indazole 
• 132283-40-0 2-(2-Methyl-2H-indazol-5-ylamino)-benzoic acid 

Relevant articles and documents

New nitroindazolylacetonitriles: Efficient synthetic access: Via vicarious nucleophilic substitution and tautomeric switching mediated by anions

New N-Alkyl-nitroindazolylacetonitriles were efficiently obtained via vicarious nucleophilic substitution of N-methyl-nitroindazoles with 4-chlorophenoxyacetonitrile. All compounds were fully characterized by NMR and mass spectroscopy techniques and the structures of some of them were additionally confirmed by X-ray diffraction analysis data. Tautomeric switching was observed in this series of nitroindazolylacetonitriles upon addition of basic anions followed by UV-Vis spectrophotometric and 1H-NMR titrations. The formation of tautomeric species induced by anionic species was endorsed by Density Functional Theory calculations.

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES

Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.