5228-77-3

Usage

Uses

Used in Pharmaceutical Research:
2-(diphenylmethyl)-1H-benzimidazole is used as a bioactive molecule for its potential therapeutic effects on various conditions. Its unique structure and properties allow it to be a candidate for drug development, with the aim of creating new treatments for a range of medical issues.
Used in Drug Development:
In the field of drug development, 2-(diphenylmethyl)-1H-benzimidazole is utilized for its potential to be formulated into new medications. Its pharmacological properties are of interest to researchers who are looking to innovate and improve upon existing treatments, offering patients more effective options for managing their health conditions.

Upstream product

• 947-91-1 Diphenylacetaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 123117-53-3 1-(dimethylamino)benzimidazole 
• 119-61-9 benzophenone 
• 862898-26-8 N-(2-aminophenyl)-2,2-dicyclohexylacetamide 
• 862898-27-9 N-(2-aminophenyl)-2,2-diphenylacetamide 
• 117-34-0 2,2-diphenylacetic acid 
• 1871-76-7 diphenylacetic acid chloride 
• 7472-60-8 N-(2-nitrophenyl)-2,2-diphenylacetamide 
• 96979-97-4 N-(2-diphenylacetylaminophenyl)-2,2-diphenylacetamide 
• 862898-33-7 N-(2-diphenylacetylaminophenyl)-2,2-dicyclohexylacetamide 
• 862898-41-7 N-[2-(2-cyclohexylacetylamino)phenyl]-2,2-diphenylacetamide 
• 862898-43-9 N-(2-phenylacetylaminophenyl)-2,2-diphenylacetamide 
• 862898-39-3 N-(2-diphenylacetylaminophenyl)-2,2-dimethylpropionamide 

Relevant academic research and scientific papers

Trichloroisocyanuric Acid/Triphenylphosphine-Mediated Synthesis of Benzimidazoles, Benzoxazoles, and Benzothiazoles

A new and efficient method for preparation of benzimidazoles, benzoxazoles, and benzothiazoles from reactions of different carboxylic acids with o-phenylenediamine, o-aminophenol, and o-aminothiophenol in the presence of triphenylphosphine/trichloroisocyanuric acid system is presented. The desired products have been characterised on the basis of spectral (infrared, NMR, mass spectrometry) data, and the mechanism of their formation is proposed. The remarkable advantages are the inexpensive and readily available reagent, simple procedure, mild conditions, and good-to-excellent yields.

MINERALOCORTICOID RECEPTOR MODULATORS

The present invention relates to diphenylmethyl imidazole mineralocorticoid receptor modulators compounds having the structure (I) and their use in treating cardiovascular events.

Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators

Design, synthesis and structure-activity relationships of benzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper. AMPK is the central component of a protein kinase cascade that plays a key role in the regulation of energy balance. Once activated, AMPK initiates a series of responses that are aimed at restoring the energy balance of the cell and recent studies have indicated that AMPK plays an important role in regulation of the whole-body energy metabolism. The following study based on the lead compound S27847 involved modification of three regions of this compound. Preliminary structure-activity relationships are being described.

Conversion of sterically hindered diacylated 1,2-phenylenediamines into 2-substituted benzimidazoles

A series of bulky 2-substituted benzimidazoles was designed in order to find new leads for several biological targets. Formation by cyclodehydration from their monoacylated counterparts was shown to be strongly dependent upon the nature of the acyl group. In the case of a dicyclohexylmethyl group, cycllzation was only observed in a p-toluenesulfonic acid/toluene mixture from the symmetrical diacylated precursor. Analysis of the mechanism was begun starting from mixed diacylated derivatives.

AN EXPEDIENT ROUTE TO 1H-BENZIMIDAZOLES AND 1H-IMIDAZOPYRIDINES

1H-Benzimidazoles, 1H-imidazopyridines, and 1H-imidazopyridines can be synthesized readily by reaction of unisolated N-(1-chloroalkyl)pyridinium chlorides with 1,2-benzenediamines, 2,3-pyridinediamine, and 3,4-pyridinediamine, respectively.

METALLATION OF 1-DIALKYLAMINOBENZIMIDAZOLES

In contrast to 1-amino- and 1-alkylaminobenzimidazoles, 1-di-alkylaminobenzimidazoles are metallated by n-butyl-lithium in absolute ether at the 2-position.The subsequent treatment of the lithium derivatives by electrophilic reagents, in which role benzop