5228-77-3

Basic information

• Product Name: 2-(diphenylmethyl)-1H-benzimidazole
• Synonyms: 1H-benzimidazole, 2-(diphenylmethyl)-
• CAS NO: 5228-77-3
• Molecular Formula: C₂₀H₁₆N₂
• Molecular Weight: 284.3544
• Mol File: 5228-77-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 528.9°C at 760 mmHg
• Flash Point: 292.5°C
• Density: 1.193g/cm³
• Vapor Pressure: 9.62E-11mmHg at 25°C
• Refractive Index: 1.682
• CAS DataBase Reference: 2-(diphenylmethyl)-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(diphenylmethyl)-1H-benzimidazole(5228-77-3)
• EPA Substance Registry System: 2-(diphenylmethyl)-1H-benzimidazole(5228-77-3)

Safety Data

• Hazardous Substances Data: 5228-77-3(Hazardous Substances Data)

Usage

General Description

2-(diphenylmethyl)-1H-benzimidazole is a chemical compound with the molecular formula C20H16N2. It is a benzimidazole derivative with a diphenylmethyl group attached to the nitrogen atom. 2-(diphenylmethyl)-1H-benzimidazole is commonly used in pharmaceutical research due to its potential biological activities, such as its ability to act as a bioactive molecule and its potential as a therapeutic agent for various conditions. Its structural features and pharmacological properties make it a promising candidate for drug development and further studies into its potential applications in medicine.

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Relevant articles and documents

Trichloroisocyanuric Acid/Triphenylphosphine-Mediated Synthesis of Benzimidazoles, Benzoxazoles, and Benzothiazoles

A new and efficient method for preparation of benzimidazoles, benzoxazoles, and benzothiazoles from reactions of different carboxylic acids with o-phenylenediamine, o-aminophenol, and o-aminothiophenol in the presence of triphenylphosphine/trichloroisocyanuric acid system is presented. The desired products have been characterised on the basis of spectral (infrared, NMR, mass spectrometry) data, and the mechanism of their formation is proposed. The remarkable advantages are the inexpensive and readily available reagent, simple procedure, mild conditions, and good-to-excellent yields.

Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators

Design, synthesis and structure-activity relationships of benzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper. AMPK is the central component of a protein kinase cascade that plays a key role in the regulation of energy balance. Once activated, AMPK initiates a series of responses that are aimed at restoring the energy balance of the cell and recent studies have indicated that AMPK plays an important role in regulation of the whole-body energy metabolism. The following study based on the lead compound S27847 involved modification of three regions of this compound. Preliminary structure-activity relationships are being described.

AN EXPEDIENT ROUTE TO 1H-BENZIMIDAZOLES AND 1H-IMIDAZOPYRIDINES

1H-Benzimidazoles, 1H-imidazopyridines, and 1H-imidazopyridines can be synthesized readily by reaction of unisolated N-(1-chloroalkyl)pyridinium chlorides with 1,2-benzenediamines, 2,3-pyridinediamine, and 3,4-pyridinediamine, respectively.