52287-58-8

Basic information

• Product Name: (E)-2,4-dichloro-1-(2-nitroprop-1-en-1-yl)benzene
• Synonyms: (E)-2,4-dichloro-1-(2-nitroprop-1-en-1-yl)benzene
• CAS NO: 52287-58-8
• Molecular Weight: 232.066
• Mol File: 52287-58-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (E)-2,4-dichloro-1-(2-nitroprop-1-en-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2,4-dichloro-1-(2-nitroprop-1-en-1-yl)benzene(52287-58-8)
• EPA Substance Registry System: (E)-2,4-dichloro-1-(2-nitroprop-1-en-1-yl)benzene(52287-58-8)

Safety Data

• Hazardous Substances Data: 52287-58-8(Hazardous Substances Data)

Upstream product

• 79-24-3 Nitroethane 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 75-52-5 nitromethane 
• 960053-43-4 C₉H₉Cl₂NO₃ 

Downstream Products

• 32560-77-3 2-(2,4-dichloro-phenyl)-1-methyl-ethylamine 
• 51146-36-2 aci-nitroethane trimethylsilyl ester 
• 143647-51-2 tetraethyl 2-(2',4'-dichlorophenyl)ethenylidenebisphosphonate 
• 89730-47-2 2-Acetyl-3-(2,4-dichlorphenyl)-4-aci-nitropentansaeure-methylester 
• 109703-73-3 3-<4-Acetyl-3-(2,4-dichlorphenyl)-2,3-dihydro-2,5-dimethyl-2-furylimino>-2,4-pentandion 
• 4380-16-9 2-Chlor-1-(2,4-dichlor-phenyl)-1-methoxy-2-nitro-propan 
• 4380-31-8 [2-bromo-1-(2,4-dichloro-phenyl)-2-nitro-propyl]-methyl ether 
• 154-98-3 2-(2,4-dichloro-phenyl)-1-methyl-ethylamine; hydrochloride 
• 1092400-98-0 2-(2,4-dichloro-phenyl)-2-methoxy-1-methyl-ethylamine 
• 1092400-96-8 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [2-(2,4-dichlorophenyl)-2-methoxyamino-1-methyl-ethyl]-amide 
• 1092400-95-7 N-[1-(2_,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide 
• 1092401-00-7 N-[2-amino-1-(2,4-dichloro-phenyl)-propyl]-O-methyl-hydroxylamine 
• 951017-42-8 N-[2-(2,4-dichlorophenyl)-1-methylethyl]-2-trifluoromethylpyrazine-3-carboxamide 
• 951017-41-7 N-[2-(2,4-dichloro-phenyl)-1-methylethyl]-2-trifluoromethylbenzamide 

Relevant articles and documents

Iron-catalyzed tandem one-pot addition and cyclization of the blaise reaction intermediate and nitroolefins: Synthesis of substituted NH-pyrroles from nitriles

The iron-catalyzed addition and cyclization of the Blaise reaction intermediate and nitroolefins to synthesize highly functionalized NH-pyrroles in a tandem one-pot manner from nitriles has been developed. This reaction shows good functional group tolerance and affords a broad spectrum of substituted NH-pyrroles in good yields. Copyright

Adapting to substrate challenges: Peptides as catalysts for conjugate addition reactions of aldehydes to α,β-disubstituted nitroolefins

Conjugate addition reactions of aldehydes to α,β-disubstituted nitroolefins are important because they provide synthetically useful γ-nitroaldehydes bearing three consecutive stereogenic centers. Such reactions are challenging due to the drastically lower reactivity of α,β-disubstituted nitroolefins compared to, for example, β-monosubstituted nitroolefins. The testing of a small collection of peptides of the type Pro-Pro-Xaa (Xaa=acidic amino acid) led to the identification of H-Pro-Pro-D-Gln-OH and H-Pro-Pro-Asn-OH as excellent stereoselective catalysts for this transformation. In the presence of 5a mol% of these peptides different combinations of aldehydes and α,β- disubstituted nitroolefins react readily with each other providing γ-nitroaldehydes in good yields and diastereoselectivities as well as excellent enantioselectivities. Chiral pyrrolidines as well as fully substituted γ-butyrolactams and γ-amino acids are easily accessible from the γ-nitroaldehydes. Mechanistic studies demonstrate that the configuration at all three stereogenic centers is induced by the peptidic catalysts. Only a minimal amount of products from homo-aldol reactions is observed demonstrating the high chemoselectivity of the peptidic catalysts. α,β- Disubstituted nitroolefins are challenging electrophiles due to their low reactivity. The modular nature of peptides of the type Pro-Pro-Xaa (Xaa=acidic amino acid; see scheme) allowed for the identification of H-Pro-Pro-D-Gln-OH and H-Pro-Pro-Asn-OH as very good catalysts for the conjugate addition reaction of aldehydes to α,β-disubstituted nitroolefins. Mechanistic studies demonstrate that the peptides induce the configuration at each of the stereogenic centers. Copyright

NOVEL MICROBIOCIDES

Compounds of formula (I) in which the substituents are as defined in claim 1,are suitable for use as microbiocides.