52311-35-0Relevant academic research and scientific papers
Simple and effective synthetic approach to chiral 2-amino-4-piperidinyl pyridine derivatives
Tian, Hua,Liu, Qing-Wen,Xu, Hao,Huang, Wen-Bo,Lin, Jian,Zhang, Suo-Qin
experimental part, p. 2707 - 2714 (2012/07/14)
(Chemical Equation Presented) A facile way has been developed to provide a series of novel chiral N-(4- (piperidin-1-yl)pyridin-2-yl)amide derivatives as potential stereoselective catalysts. The key intermediate, 2-amino-4-piperidinyl pyridine, was obtained by nucleophilic substitution of 2-amino-4-chloropyridine with piperidine in good yields (up to 96%). The total control of enantioselectivity was obtained for the synthesis of L-proline and (R)-1,10-bi(2-naphthol) derivatives. Copyright Taylor & Francis Group, LLC.
