52311-59-8

Basic information

• Product Name: 4-Chloro-2-nitrobenzyl bromide
• Synonyms: 4-Chloro-2-nitrobenzyl bromide;2-Nitro-4-chlorobenzyl bromide
• CAS NO: 52311-59-8
• Molecular Formula: C₇H₅BrClNO₂
• Molecular Weight: 250.4771
• Mol File: 52311-59-8.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Chloro-2-nitrobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-2-nitrobenzyl bromide(52311-59-8)
• EPA Substance Registry System: 4-Chloro-2-nitrobenzyl bromide(52311-59-8)

Safety Data

• Hazardous Substances Data: 52311-59-8(Hazardous Substances Data)

Usage

General Description

4-Chloro-2-nitrobenzyl bromide is a chemical compound with the molecular formula C7H5ClBrNO2. It is a pale yellow solid that is used as a reagent in organic synthesis. 4-Chloro-2-nitrobenzyl bromide is often employed in the production of pharmaceuticals, agrochemicals, and dyes. It is a versatile intermediate that can undergo various reactions, including nucleophilic substitution and reduction, to yield a wide range of useful compounds. 4-Chloro-2-nitrobenzyl bromide is considered to be a hazardous material and should be handled with care and proper safety precautions.

Upstream product

• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 22996-18-5 (4-chloro-2-nitrophenyl)methanol 
• 89-59-8 4-chloro-2-nitrotoluene 

Downstream Products

• 85062-27-7 (4-Chloro-2-nitro-benzyl)-(4-methoxy-benzyl)-amine; hydrochloride 
• 922711-92-0 C₁₀H₈ClN₃O₂ 
• 1269005-12-0 4-chloro-1-(2-methylbenzyl)-2-nitrobenzene 
• 1269005-14-2 5-chloro-2-(2-methylbenzyl)aniline 
• 114688-64-1 2-(2-nitro-4-chlorobenzyl)-1,2,3,4-tetrahydroisoquinoline 
• 56465-80-6 2-(4-Chlor-2-nitro-benzyl)-2-acetamino-malonsaeure-diethylester 
• 120975-21-5 2-benzyl-5-chloroaniline 
• 1422192-29-7 8-chloro-2-(phenylsulfonyl)-1,2,3,4,5,6-hexahydroazepino[4,3-b]indole 
• 1422193-04-1 3-chloro-6-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline 
• 49641-17-0 trans-4,4'-dichloro-2,2'-dinitrostilbene 
• 1333547-33-3 4-chloro-2-nitrobenzyltriphenylphosphonium bromide 
• 1148-57-8 4-chloro-2-nitrobenzylsulfonylacetic acid 

Relevant articles and documents

3-OXAZOLINONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention relates to a novel 3-indazolinone compound that regulates or inhibits the activity of indoleamine 2,3-dioxygenase (IDO), the method for the preparation thereof and the use thereof in medicine. In particular, the present invention relates to a compound represented by the general formula (I) and a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof, a method for treating or preventing IDO-mediated diseases, especially tumors, by use of the compound or a pharmaceutically acceptable salt thereof, and a method for preparing the compound or a pharmaceutically acceptable salt thereof. The present invention further relates to use of the compound or a pharmaceutically acceptable salt thereof or a composition comprising the compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for treating or preventing IDO-mediated diseases, especially tumors.Wherein the substituents of the general formula (I) are defined the same as that in the specification.

Access to Chiral Seven-Member Cyclic Amines via Rh-Catalyzed Asymmetric Hydrogenation

A highly efficient asymmetric hydrogenation of azepine/oxazepine-type seven-member cyclic imine hydrochlorides was successfully developed using Rh/bisphosphine-thiourea ligand ZhaoPhos, affording various chiral seven-member cyclic amines with full conversions, high yields, and excellent enantioselectivities (up to 96% yield, >99% ee). Additionally, this asymmetric hydrogenation can proceed well on gram scale with excellent ee value. Moreover, control experimental results displayed that the anion-bonding interaction between the chloride ion of the substrate and thiourea motif of the ZhaoPhos played an important role to obtain excellent enantioselectivity.

Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2′,4′,6′-trimethoxystyrylsulfonyl)methyl] phenylamino}acetate (ON 01910.Na): Synthesis, structure-activity relationship, and biological activity

Cyclin D proteins are elevated in many cancer cells, and targeted deletion of cyclin D1 gene in the mammary tissues protects mice from breast cancer. Accordingly, there is an increasing awareness of this novel nonenzymatic target for cancer therapeutics. We have developed novel, nonalkylating styrylbenzylsulfones that induce cell death in wide variety of cancer cells without affecting the proliferation and survival of normal cells. The development of derivatized styrylbenzylsulfones followed logically from a tumor cell cytotoxicity screen performed in our laboratory that did not have an a priori target profile. Modifications of some of the precursor molecules led to lead optimization with regard to tumor cell cytotoxicity. In this report we describe the synthesis and structure-activity relationships of novel, nonalkylating (E)-styrylbenzylsulfones and the development of the novel anticancer agent sodium (E)-2-{2-methoxy-5-[(2′,4′,6′- trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na), which is in phase III trials for myelodysplastic syndromes (MDS) associated with aberrant expression of cyclin D proteins.