52323-07-6Relevant academic research and scientific papers
Nitroalkanes as alkyl anion synthons - A new approach to the synthesis of 2-substituted N-ethyl succinimides and 2-substituted succinate diesters via nitroalkanes
Ballini, Roberto,Bosica, Giovanna
, p. 2087 - 2089 (2007/10/03)
2-Substituted N-ethyl succinimide and 2-substituted succinate diesters were obtained by two key steps: (i) Michael addition of a nitroalkane to the appropriate enedione derivative under basic conditions (DBU), with the concomitant elimination of nitrous acid, and (ii) selective reduction of the obtained enone with nickel boride, in methanol/THF. In this context the nitroalkane acts as an alkyl anion synthon. By this method trimethyl tricarboxylates were also synthesized. VCH Verlagsgesellschaft mbH, 1996.
